Surgical resection of pancreatic insulinoma during pregnancy: Case report and literature review

INTRODUCTION: Insulinomas are neuroendocrine tumors characterized by an excessive secretion of insulin, and its most common primary site is the pancreas. PRESENTATION OF THE CASE: Female, 31 years old, who underwent surgical resection of a pancreatic insulinoma measuring 0.5 x 0.5 cm during the third trimester of pregnancy. The patient started to present characteristic symptoms (hypoglycemia, adrenergic and neuroglycopenic symptoms) 18 months before being referred to our center. It was decided to resect the lesion due to the intensity of the symptoms and failure of the clinical treatment. The postoperative course was uneventful, and the fetus presented good vitality, as evidenced by the obstetric ultrasound. The patient was discharged from the hospital on the 6th postoperative day. The neonate was born at term, 38 weeks, with appropriate weight for gestational age. Today, around 12 months after surgery, the patient and the infant are in good health conditions and have no complaints. CONCLUSION: The moment of the surgical intervention in our case reflects the importance of this report, since it reinforces the feasibility of this procedure during pregnancy. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.