Pulmonary hypertension reported with immune checkpoint inhibitors: a pharmacovigilance study

被引：9

作者：

Palassin, Pascale ^{[1
]}

Maria, Alexandre T. J. ^{[2
,3
]}

Ladhari, Chayma ^{[1
]}

Quantin, Xavier ^{[4
]}

Montani, David ^{[5
,6
,7
]}

Bourdin, Arnaud ^{[8
,9
]}

Boissin, Clement ^{[8
]}

Fesler, Pierre ^{[9
,10
]}

Hillaire-Buys, Dominique ^{[1
]}

Guilpain, Philippe ^{[2
,3
]}

Faillie, Jean-Luc ^{[1
,11
]}

机构：

[1] Univ Hosp, Dept Med Pharmacol & Toxicol, Montpellier, France

[2] Montpellier Univ Hosp, St Eloi Hosp, Local Referral Ctr Rare Autoimmune Dis, Dept Internal Med Multiorgan Dis, Montpellier, France

[3] Univ Montpellier, IRMB, Montpellier, France

[4] Univ Montpellier, Montpellier Canc Inst, Dept Med Oncol, Thorac Oncol, Montpellier, France

[5] Univ Paris Saclay, Sch Med, Le Kremlin Bicetre, France

[6] Hop Marie Lannelongue, INSERM UMR S 999, Le Plessis Robinson, France

[7] Hop Bicetre, AP HP, Dept Resp & Intens Care Med, Le Kremlin Bicetre, France

[8] Univ Montpellier, CHU Montpellier, Dept Resp Dis, Montpellier, France

[9] Univ Montpellier, CNRS UMR 9214, INSERM U1046, PhyMedExp, Montpellier, France

[10] Montpellier Univ Hosp, Lapeyronie Hosp, Dept Internal Med & Arterial Hypertens, Montpellier, France

[11] Univ Montpellier, INSERM, IDESP, Montpellier, France

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2022年 / 71卷 / 12期

关键词：

Pulmonary hypertension; Immune checkpoint inhibitors; Pharmacovigilance; Auto-immune disorders; Adverse drug reactions; ADVANCED CANCER; PNEUMONITIS;

D O I：

10.1007/s00262-022-03208-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors (ICI) restore immune response against cancer cells that can lead to immune-related adverse effects. While cardiovascular immune-related adverse effects are known to be associated with checkpoint inhibitors, recent case reports have raised concerns about the potential association with pulmonary hypertension (PH). By using the global pharmacovigilance database VigiBase, we investigated the onset of PH associated with ICI and propose a comprehensive description of the 42 cases of PH reported with ICI recorded in this database. Through this study and review of the cases published in the literature, we discuss the possible link between PH and ICI in the context of cancer in order to better understand this rare but potentially fatal event.

引用

页码：3093 / 3097

页数：5

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