Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa

被引:21
作者
Antonelli, Giada [1 ,2 ]
Cappelli, Luigia [1 ,3 ]
Cinelli, Paolo [1 ,3 ]
Cuffaro, Rossella [1 ,2 ]
Manca, Benedetta [1 ,3 ]
Nicchi, Sonia [1 ,3 ]
Tondi, Serena [1 ,4 ]
Vezzani, Giacomo [1 ,3 ]
Viviani, Viola [1 ,3 ]
Delany, Isabel [1 ]
Scarselli, Maria [1 ]
Schiavetti, Francesca [1 ]
机构
[1] GSK Vaccines, I-53100 Siena, Italy
[2] Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy
[3] Univ Bologna, Dept Pharm & Biotechnol FABIT, I-40126 Bologna, Italy
[4] Univ Siena, Dept Life Sci, I-53100 Siena, Italy
关键词
Escherichia coli; Pseudomonas aeruginosa; antimicrobial resistance (AMR); antigen identification; vaccine; monoclonal antibodies (mAbs); outer membrane vesicles (OMV); OUTER-MEMBRANE VESICLES; URINARY-TRACT-INFECTIONS; MOLECULAR-MECHANISMS; VACCINE; BACTERIA; MANAGEMENT; EPIDEMIOLOGY; TRANSMISSION; PATHOGENESIS; ANTIBIOTICS;
D O I
10.3390/ijms22094943
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Traditional antimicrobial treatments consist of drugs which target different essential functions in pathogens. Nevertheless, bacteria continue to evolve new mechanisms to evade this drug-mediated killing with surprising speed on the deployment of each new drug and antibiotic worldwide, a phenomenon called antimicrobial resistance (AMR). Nowadays, AMR represents a critical health threat, for which new medical interventions are urgently needed. By 2050, it is estimated that the leading cause of death will be through untreatable AMR pathogens. Although antibiotics remain a first-line treatment, non-antibiotic therapies such as prophylactic vaccines and therapeutic monoclonal antibodies (mAbs) are increasingly interesting alternatives to limit the spread of such antibiotic resistant microorganisms. For the discovery of new vaccines and mAbs, the search for effective antigens that are able to raise protective immune responses is a challenging undertaking. In this context, outer membrane vesicles (OMV) represent a promising approach, as they recapitulate the complete antigen repertoire that occurs on the surface of Gram-negative bacteria. In this review, we present Escherichia coli and Pseudomonas aeruginosa as specific examples of key AMR threats caused by Gram-negative bacteria and we discuss the current status of mAbs and vaccine approaches under development as well as how knowledge on OMV could benefit antigen discovery strategies.
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页数:18
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