Indoleamine 2,3-Dioxygenase Inhibitors Isolated from the Sponge Xestospongia vansoesti: Structure Elucidation, Analogue Synthesis, and Biological Activity

被引：24

作者：

Centko, Ryan M. ^{[1
,2
]}

Steino, Anne ^{[3
]}

Rosell, Federico I. ^{[3
]}

Patrick, Brian O. ^{[1
]}

de Voogd, Nicole ^{[4
]}

Mauk, A. Grant ^{[3
]}

Andersen, Raymond J. ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

[4] Netherlands Ctr Biodivers Nat, NL-2300 RA Leiden, Netherlands

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 24期

关键词：

HALENAQUINONE DERIVATIVES; IDO; CANCER; XESTOQUINONE; INFLAMMATION;

D O I：

10.1021/ol503337f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new IDO inhibitory meroterpenoids, xestolactone A (1) and xestosaprol O (2), have been isolated from the sponge Xestospongia vansoesti. Xestolactone A (1) has an unprecedented degraded meroterpenoid carbon skeleton. A short synthesis of the xestosaprol O (2) analogues 3 and 4 features the application of a rarely used photochemical coupling reaction. Synthetic analogue 3 is similar to 40 times more potent than the inspirational natural product 2.

引用

页码：6480 / 6483

页数：4

共 24 条

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