Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians

被引：8

作者：

Zhu, Jingwen ^{[1
]}

Manichaikul, Ani ^{[2
,3
]}

Hu, Yao ^{[1
]}

Chen, Yii-Der I. ^{[4
]}

Liang, Shuang ^{[5
]}

Steffen, Lyn M. ^{[6
]}

Rich, Stephen S. ^{[2
]}

Tsai, Michael ^{[5
]}

Siscovick, David S. ^{[7
,8
]}

Lemaitre, Rozenn N. ^{[7
]}

Li, Huaixing ^{[1
]}

Lin, Xu ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China

[2] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

[3] Univ Virginia, Div Biostat & Epidemiol, Dept Publ Hlth Sci, Charlottesville, VA USA

[4] Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA

[5] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[7] Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA

[8] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

来源：

EUROPEAN JOURNAL OF NUTRITION | 2017年 / 56卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Myristic acid; Arachidic acid; Genome-wide association study; Chinese; Lipids; CORONARY-HEART-DISEASE; DE-NOVO LIPOGENESIS; MIDDLE-AGED ADULTS; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; OLDER CHINESE; EXPRESSION; MARKERS;

D O I：

10.1007/s00394-016-1193-1

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians. Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry. We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 x 10(-9) and P = 4.33 x 10(-8), respectively), and a novel 20:0-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 x 10(-10)). We also confirmed the previously reported association of FADS1/2-rs102275 with 18:0 (P = 1.12 x 10(-5)). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in CERS4 also exhibited evidence of associations with high-density lipoprotein cholesterol (P = 0.0162 and P = 0.0161, respectively). To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body.

引用

页码：1477 / 1484

页数：8

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