Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases

被引：121

作者：

Cheng, Li-Xia ^{[1
]}

Tang, Jiang-Jiang ^{[1
]}

Luo, Hui ^{[2
]}

Jin, Xiao-Ling ^{[1
]}

Dai, Fang ^{[1
]}

Yang, Jie ^{[1
]}

Qian, Yi-Ping ^{[1
]}

Li, Xiu-Zhuang ^{[1
]}

Zhou, Bo ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Jinggangshan Univ, Sch Med, Jian 343009, Jiangxi, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Schiff bases; Antioxidant; Galvinoxyl radical; DNA; Antiproliferative effect; Structure-activity relationship; TRANS-RESVERATROL; FREE-RADICALS; RAT HEARTS; MECHANISM; ANALOGS; PEROXIDATION; SOLVENT;

D O I：

10.1016/j.bmcl.2010.03.039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight hydroxyl-substituted Schiff bases with the different number and position of hydroxyl group on the two asymmetric aromatic rings ( A and B rings) were prepared by the reaction between the corresponding aromatic aldehyde and aniline. Their antioxidant effects against the stable galvinoxyl radical (GO(center dot)) in ethyl acetate and methanol, and 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced DNA strand breakage, and their antiproliferative effects on human hepatoma HepG2 cells, were investigated. Structure-activity relationship analysis demonstrates that o-dihydroxyl groups on the aromatic A ring and 4-hydroxyl group attached to the aromatic B ring contribute critically to the antioxidant and antiproliferative activities. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2417 / 2420

页数：4

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