Involvement of hypoglossal and recurrent laryngeal nerves on swallowing pressure

被引:17
作者
Tsujimura, Takanori [1 ]
Suzuki, Taku [1 ]
Yoshihara, Midori [1 ]
Sakai, Shogo [1 ]
Koshi, Naomi [1 ]
Ashiga, Hirokazu [1 ,2 ]
Shiraishi, Naru [1 ]
Tsuji, Kojun [1 ]
Magara, Jin [1 ]
Inoue, Makoto [1 ]
机构
[1] Niigata Univ, Div Dysphagia Rehabil, Grad Sch Med & Dent Sci, Niigata, Japan
[2] Niigata Univ Rehabil, Dept Rehabil, Murakami, Niigata, Japan
基金
日本学术振兴会;
关键词
hypoglossal nerve; oropharynx; recurrent laryngeal nerve; upper esophageal sphincter; UPPER ESOPHAGEAL SPHINCTER; OROPHARYNGEAL DYSPHAGIA; PHARYNGEAL BRANCH; ANESTHETIZED RATS; VAGUS NERVE; STIMULATION; MECHANISMS; INNERVATION; ASPIRATION; PARALYSIS;
D O I
10.1152/japplphysiol.00944.2017
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Swallowing pressure generation is important to ensure safe transport of an ingested bolus without aspiration or leaving residue in the pharynx. To clarify the mechanism, we measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) using a specially designed manometric catheter in anesthetized rats. A swallow, evoked by punctate mechanical stimulation to the larynx, was identified by recording activation of the suprahyoid and thyrohyoid muscles using electromyography (EMG). Areas under the curve of the swallowing pressure at the OP, UES, and CE from two trials indicated high intrasubject reproducibility. Effects of transecting the hypoglossal nerve (12N) and recurrent laryngeal nerve (RLN) on swallowing were investigated. Following bilateral hypoglossal nerve transection (Bi-12Nx), OP pressure was significantly decreased, and time intervals between peaks of thyrohyoid EMG bursts and OP pressure were significantly shorter. Decreased OP pressure and shortened times between peaks of thyrohyoid EMG bursts and OP pressure following Bi-12Nx were significantly increased and longer, respectively, after covering the hard and soft palates with acrylic material. UES pressure was significantly decreased after bilateral RLN transection compared with that before transection. These results suggest that the 12N and RLN play crucial roles in OP and UES pressure during swallowing, respectively. We speculate that covering the palates with a palatal augmentation prosthesis may reverse the reduced swallowing pressure in patients with 12N or tongue damage by the changes of the sensory information and of the contact between the tongue and a palates. NEW & NOTEWORTHY Hypoglossal nerve transection reduced swallowing pressure at the oropharynx. Covering the hard and soft palates with acrylic material may reverse the reduced swallowing function caused by hypoglossal nerve damage. Recurrent laryngeal nerve transection reduced upper esophageal sphincter negative pressure during swallowing.
引用
收藏
页码:1148 / 1154
页数:7
相关论文
共 37 条
[11]   Pharyngeal branch of the glossopharyngeal nerve plays a major role in reflex swallowing from the pharynx [J].
Kitagawa, JI ;
Shingai, T ;
Takahashi, Y ;
Yamada, Y .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2002, 282 (05) :R1342-R1347
[12]   Postdeglutitive residue in vagus nerve paralysis and its association with feeding style [J].
Kumai, Yoshihiko ;
Samejima, Yasuhiro ;
Yumoto, Eiji .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2016, 273 (12) :4369-4375
[13]   Dehydration among long-term care elderly patients with oropharyngeal dysphagia [J].
Leibovitz, A. ;
Baumoehl, Y. ;
Lubart, E. ;
Yaina, A. ;
Platinovitz, N. ;
Segal, R. .
GERONTOLOGY, 2007, 53 (04) :179-183
[14]  
MCCONNEL FMS, 1988, LARYNGOSCOPE, V98, P71
[15]   Three-dimensional manometry of the upper esophageal sphincter in swallowing and nonswallowing tasks [J].
Meyer, Jacob P. ;
Jones, Corinne A. ;
Walczak, Chelsea C. ;
McCulloch, Timothy M. .
LARYNGOSCOPE, 2016, 126 (11) :2539-2545
[16]   The innervation of the human upper esophageal sphincter [J].
Mu, LC ;
Sanders, I .
DYSPHAGIA, 1996, 11 (04) :234-238
[17]   Human Tongue Neuroanatomy: Nerve Supply and Motor Endplates [J].
Mu, Liancai ;
Sanders, Ira .
CLINICAL ANATOMY, 2010, 23 (07) :777-791
[18]   The Human Cricothyroid Muscle: Three Muscle Bellies and Their Innervation Patterns [J].
Mu, Liancai ;
Sanders, Ira .
JOURNAL OF VOICE, 2009, 23 (01) :21-28
[19]   Effects of pharyngeal water stimulation on swallowing behaviors in healthy humans [J].
Nakamura, Yuki ;
Hatakeyama, Aya ;
Kitada, Yasuyuki ;
Tsujimura, Takanori ;
Taniguchi, Hiroshige ;
Inoue, Makoto .
EXPERIMENTAL BRAIN RESEARCH, 2013, 230 (02) :197-205
[20]   High Resolution Manometry Analysis of a Patient With Dysphagia After Occiput-C3/4 Posterior Fusion Operation [J].
Oh, Yoongul ;
Lee, Seok Tae ;
Ryu, Ju Seok .
ANNALS OF REHABILITATION MEDICINE-ARM, 2015, 39 (06) :1028-1032