AMYLOID IMAGING IN ALZHEIMER'S DISEASE: A LITERATURE REVIEW

被引：1

作者：

Saidlitz, P. ^{[1
]}

Voisin, T. ^{[1
,2
,3
]}

Vellas, B. ^{[1
,3
]}

Payoux, P. ^{[2
,4
]}

Gabelle, A. ^{[5
,6
]}

Formaglio, M. ^{[7
]}

Delrieu, J. ^{[1
]}

机构：

[1] Purpan Univ Hosp, Alzheimers Dis Ctr, F-31059 Toulouse 09, France

[2] Purpan Univ Hosp, Nucl Imaging Dept, F-31059 Toulouse 09, France

[3] INSERM, UMR1027, Fac Med, F-31062 Toulouse, France

[4] Toulouse Univ, INSERM, UMr 825, Toulouse 3, France

[5] Univ Gui de Chauliac Hosp, Res & Memory Ctr Montpellier, Montpellier, France

[6] INSERM, U1040, Biotherapy Inst, Montpellier, France

[7] Hosp Civils Lyon, Hop Neurol, Serv Neurol D, Dept Neurol, Lyon, France

来源：

JOURNAL OF NUTRITION HEALTH & AGING | 2014年 / 18卷 / 07期

关键词：

Amyloid imaging; Alzheimer's disease; biomarkers; amyloid-beta peptide; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; PITTSBURGH-COMPOUND-B; FLORBETAPIR F 18; NORMAL OLDER-ADULTS; A-BETA DEPOSITION; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; APOE GENOTYPE;

D O I：

10.1007/s12603-014-0507-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Therapies targeting amyloid-beta peptide currently represent approximately 50% of drugs now being developed for Alzheimer's disease. Some, including active and passive anti-beta immunotherapy, directly target the amyloid plaques. The new amyloid tracers are increasingly being included in the proposed updated diagnostic criteria, and may allow earlier diagnosis. Those targeting amyloid-beta peptide allow identification of amyloid plaques in vivo. We need to gain insight into all aspects of their application. As florbetapir (Amyvid (TM)) and flutemetamol (Vizamyl (TM)) have received marketing authorization, clinicians require deeper knowledge to be rationally used in diagnosis. In this paper, we review both completed and ongoing observational, longitudinal and interventional studies of these tracers, our main objective being to show the performance of the four most commonly used tracers and their validation.

引用

页码：723 / 740

页数：18

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