Efficacy, safety and quality of life in patients receiving subcutaneous IgG treatment: experience in Bogota, Colombia

被引:3
作者
Claudia Ortega-Lopez, Maria [1 ]
Garay, Javier [2 ]
Leon Piniila, Monica [1 ]
机构
[1] Hosp Infantil Univ San Jose, Dept Pediat, Carrera 52 67A-71, Bogota, Colombia
[2] Pontificia Univ Javeriana, Dept Epidemiol Clin, Bogota, Colombia
关键词
primary immunodeficiencies; replacement therapy; SCIG; subcutaneous immunoglobulin; PRIMARY IMMUNODEFICIENCY DISEASES; PRIMARY ANTIBODY DEFICIENCIES; GENERIC CORE SCALES; IMMUNOGLOBULIN REPLACEMENT; TREATMENT-SATISFACTION; SELF-INFUSIONS; CHILDREN; THERAPY; RELIABILITY; VALIDITY;
D O I
10.2217/imt-2018-0038
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Aim: Investigate efficacy, safety and quality of life of Gammanorm (R) 16.5% (subcutaneous immunoglobulin [SCIG]) in patients with primary immunodeficiencies (PIDs) and safety and to lesser extent efficacy in autoimmune diseases. Patients & methods: Medical records were extracted from 31 pediatric and 12 adult patients who received SCIG as part of the Personalized Program at University Children's Hospital, Bogota, Colombia. Results: Mean SCIG dose was 28.7 g/month. Serious bacterial infections were observed in 7/33 patients in the PID group, most often bacterial pneumonia (3/33). There were no serious adverse events related to SCIG treatment. Drug-related adverse reactions were reported in 2/43 patients. Conclusion: Self-administration of SCIG provided effective protection, favorable tolerability and improved quality of life in patients with PIDs and autoimmune diseases from Colombia.
引用
收藏
页码:861 / 869
页数:9
相关论文
共 39 条
[1]  
Abrahamsen TG, 1996, PEDIATRICS, V98, P1127
[2]   Incidence of Infection is Inversely Related to Steady-State (Trough) Serum IgG Level in Studies of Subcutaneous IgG in PIDD [J].
Berger, Melvin .
JOURNAL OF CLINICAL IMMUNOLOGY, 2011, 31 (05) :924-926
[3]   Improved Quality of Life, Immunoglobulin G Levels, and Infection Rates in Patients with Primary Immunodeficiency Diseases during Self-Treatment with Subcutaneous Immunoglobulin G [J].
Berger, Melvin ;
Murphy, Elyse ;
Riley, Patty ;
Bergman, Garrett E. .
SOUTHERN MEDICAL JOURNAL, 2010, 103 (09) :856-863
[4]   Subcutaneous Administration of IgG [J].
Berger, Melvin .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2008, 28 (04) :779-802
[5]   Comparative Study of Subcutaneous Versus Intravenous IgG Replacement Therapy in Pediatric Patients with Primary Immunodeficiency Diseases: A Multicenter Study in Argentina [J].
Bezrodnik, Liliana ;
Gomez Raccio, Andrea ;
Belardinelli, Gabriela ;
Regairaz, Lorena ;
Diaz Ballve, Damacia ;
Seminario, Gisela ;
Moreira, Ileana ;
Riganti, Carlos ;
Cantisano, Claudio ;
Diaz, Hector ;
Di Giovanni, Daniela .
JOURNAL OF CLINICAL IMMUNOLOGY, 2013, 33 (07) :1216-1222
[6]   Self-infusion Programmes for Immunoglobulin Replacement at Home: Feasibility, Safety and Efficacy [J].
Bhole, Malini V. ;
Burton, Janet ;
Chapel, Helen M. .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2008, 28 (04) :821-832
[7]   The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies [J].
Bousfiha, Aziz ;
Jeddane, Leila ;
Picard, Capucine ;
Ailal, Fatima ;
Gaspar, H. Bobby ;
Al-Herz, Waleed ;
Chatila, Talal ;
Crow, Yanick J. ;
Cunningham-Rundles, Charlotte ;
Etzioni, Amos ;
Luis Franco, Jose ;
Holland, Steven M. ;
Klein, Christoph ;
Morio, Tomohiro ;
Ochs, Hans D. ;
Oksenhendler, Eric ;
Puck, Jennifer ;
Tang, Mimi L. K. ;
Tangye, Stuart G. ;
Torgerson, Troy R. ;
Casanova, Jean-Laurent ;
Sullivan, Kathleen E. .
JOURNAL OF CLINICAL IMMUNOLOGY, 2018, 38 (01) :129-143
[8]  
BRUTON OC, 1952, PEDIATRICS, V9, P722
[9]  
Amaya-Arias AC, 2017, INT J PREVENTIVE MED, V8, DOI 10.4103/ijpvm.IJPVM_194_16
[10]   The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy [J].
Chapel, HM ;
Spickett, GP ;
Ericson, D ;
Engl, W ;
Eibl, MM ;
Bjorkander, J .
JOURNAL OF CLINICAL IMMUNOLOGY, 2000, 20 (02) :94-100