OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

被引：84
作者：
Zhou, Honghong [1 ,2 ,3 ]
Liu, Yongshuo [1 ,2 ]
Zhu, Rui [1 ,2 ]
Ding, Fang [1 ,2 ]
Cao, Xiufeng [4 ]
Lin, Dongxin [1 ,2 ,3 ]
Liu, Zhihua [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China
[4] Nanjing Med Univ, Nanjing Hosp 1, Dept Surg Oncol, Nanjing, Jiangsu, Peoples R China
来源：
ONCOGENE | 2018年 / 37卷 / 25期
基金：
国家重点研发计划; 美国国家科学基金会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR SNAIL; BREAST-CANCER; POOR-PROGNOSIS; DEGRADATION; INVASION; EMT; DEUBIQUITINATION; PROGRESSION; ENZYME;
D O I：
10.1038/s41388-018-0224-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Snail is a key regulator of epithelial-mesenchymal transition (EMT) and plays an important role in tumor progression and metastasis. Snail is rapidly degraded in the cells and its protein level is critically controlled. Although several E3 ligases regulating Snail degradation have been defined, the deubiquitinases (DUBs) responsible for Snail deubiquitination are less studied. We identified ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) as a DUB that stabilizes Snail through preventing its ubiquitination and proteasomal degradation. Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability. Moreover, OTUB1 is highly expressed in ESCC and higher expression of OTUB1 predicts poor prognosis. These findings suggest that OTUB1 is an essential regulator of Snail and plays a critical role in facilitating esophageal cancer progression.
引用
收藏
页码：3356 / 3368
页数：13
相关论文
共 50 条
[21]   FOXQ1 promotes gastric cancer metastasis through upregulation of Snail [J].
Zhang, Jing ;
Liu, Yimin ;
Zhang, Jia ;
Cui, Xiaohai ;
Li, Gang ;
Wang, Jiansheng ;
Ren, Hong ;
Zhang, Yunfeng .
ONCOLOGY REPORTS, 2016, 35 (06) :3607-3613
[22]   SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4 [J].
Zhang, Jianglan ;
Luo, Aiping ;
Huang, Furong ;
Gong, Tongyang ;
Liu, Zhihua .
CANCER LETTERS, 2020, 469 :390-398
[23]   Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma [J].
Yang, Huilun ;
Hu, Haiyang ;
Gou, Yanling ;
Hu, Yuhong ;
Li, Hui ;
Zhao, Hongwei ;
Wang, Beidi ;
Li, Peiling ;
Zhang, Zongfeng .
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2018, 23 (02) :321-328
[24]   Expression of Twist, Slug and Snail in esophageal squamous cell carcinoma and their prognostic significance [J].
Xu, Shanshan ;
Zhou, Yaxing ;
Biekemitoufu, Hadeti ;
Wang, Hui ;
Li, Chao ;
Zhang, Wenjing ;
Ma, Yuqing .
ONCOLOGY LETTERS, 2021, 21 (03)
[25]   TBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma [J].
Liu, Liping ;
Lin, Chuyong ;
Liang, Weijiang ;
Wu, Shu ;
Liu, Aibin ;
Wu, Jueheng ;
Zhang, Xin ;
Ren, Pengli ;
Li, Mengfeng ;
Song, Libing .
GUT, 2015, 64 (01) :26-36
[26]   USP18 promotes tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1 [J].
Song, Chao ;
Peng, Jinhua ;
Wei, Yiping ;
Shao, Jun ;
Chen, Xianglai ;
Zhang, Xiaoqiang ;
Xu, Jianjun .
EXPERIMENTAL CELL RESEARCH, 2021, 409 (01)
[27]   Upregulation of long noncoding RNA SPRY4-IT1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial-mesenchymal transition [J].
Zhang, Chun-Yang ;
Li, Ren-Ke ;
Qi, Yu ;
Li, Xiang-Nan ;
Yang, Yang ;
Liu, Dong-Lei ;
Zhao, Jia ;
Zhu, Deng-Yan ;
Wu, Kai ;
Zhou, Xu-Dong ;
Zhao, Song .
CELL BIOLOGY AND TOXICOLOGY, 2016, 32 (05) :391-401
[28]   MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis [J].
Li, Ming ;
He, Xiao-Yan ;
Zhang, Zhi-Mei ;
Li, Shuo ;
Ren, Li-Hua ;
Cao, Ri-Sheng ;
Feng, Ya-Dong ;
Ji, Yin-Lin ;
Zhao, Ye ;
Shi, Rui-Hua .
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (11) :3245-3255
[29]   HCRP1 inhibits cell proliferation and invasion and promotes chemosensitivity in esophageal squamous cell carcinoma [J].
Wu, Yu ;
Yang, Ye ;
Xian, Yin-Sheng .
CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 308 :357-363
[30]   Nuclear expression of Twist promotes lymphatic metastasis in esophageal squamous cell carcinoma [J].
Gong, Taiqian ;
Xue, Zengfu ;
Tang, Shanhong ;
Zheng, Xiushan ;
Xu, Guanghui ;
Gao, Liucun ;
Zhao, Guohong ;
Hong, Liu ;
Tang, Guangbo ;
Zhang, Hongwei ;
Wang, Ruwen ;
Jiang, Yaoguang ;
Fan, Daiming .
CANCER BIOLOGY & THERAPY, 2012, 13 (08) :606-613
12345