OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

被引：86

作者：

Zhou, Honghong ^{[1
,2
,3
]}

Liu, Yongshuo ^{[1
,2
]}

Zhu, Rui ^{[1
,2
]}

Ding, Fang ^{[1
,2
]}

Cao, Xiufeng ^{[4
]}

Lin, Dongxin ^{[1
,2
,3
]}

Liu, Zhihua ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China

[2] Peking Union Med Coll, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China

[4] Nanjing Med Univ, Nanjing Hosp 1, Dept Surg Oncol, Nanjing, Jiangsu, Peoples R China

来源：

ONCOGENE | 2018年 / 37卷 / 25期

基金：

美国国家科学基金会; 国家重点研发计划;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR SNAIL; BREAST-CANCER; POOR-PROGNOSIS; DEGRADATION; INVASION; EMT; DEUBIQUITINATION; PROGRESSION; ENZYME;

D O I：

10.1038/s41388-018-0224-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Snail is a key regulator of epithelial-mesenchymal transition (EMT) and plays an important role in tumor progression and metastasis. Snail is rapidly degraded in the cells and its protein level is critically controlled. Although several E3 ligases regulating Snail degradation have been defined, the deubiquitinases (DUBs) responsible for Snail deubiquitination are less studied. We identified ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) as a DUB that stabilizes Snail through preventing its ubiquitination and proteasomal degradation. Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability. Moreover, OTUB1 is highly expressed in ESCC and higher expression of OTUB1 predicts poor prognosis. These findings suggest that OTUB1 is an essential regulator of Snail and plays a critical role in facilitating esophageal cancer progression.

引用

页码：3356 / 3368

页数：13

共 50 条

[1] USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail [J].

Li, Lei ;

Zhou, Honghong ;

Zhu, Rui ;

Liu, Zhihua .

CANCER LETTERS, 2019, 448 :52-60

[2] Targeting and degradation of OTUB1 by Erianin for antimetastasis in esophageal squamous cell carcinoma [J].

Zhu, Yuan ;

Kang, Ningning ;

Zhang, Li ;

Tao, Jianju ;

Xue, Wen ;

Li, Hui ;

Li, Yingcan ;

Zheng, Xucai ;

He, Wei ;

Ma, Junting .

PHYTOMEDICINE, 2024, 135

[3] EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability [J].

Guo, Xiaobin ;

Zhu, Rui ;

Luo, Aiping ;

Zhou, Honghong ;

Ding, Fang ;

Yang, Hongxin ;

Liu, Zhihua .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)

[4] Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma [J].

Zhu, Rui ;

Liu, Yongshuo ;

Zhou, Honghong ;

Li, Lei ;

Li, Yi ;

Ding, Fang ;

Cao, Xiufeng ;

Liu, Zhihua .

CANCER LETTERS, 2018, 418 :125-134

[5] EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability [J].

Xiaobin Guo ;

Rui Zhu ;

Aiping Luo ;

Honghong Zhou ;

Fang Ding ;

Hongxin Yang ;

Zhihua Liu .

Journal of Experimental & Clinical Cancer Research, 39

[6] OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer [J].

Zhou, Yi ;

Wu, Jiangxue ;

Fu, Xiang ;

Du, Wuying ;

Zhou, Ling ;

Meng, Xiangqi ;

Yu, Hongyan ;

Lin, Jiaxin ;

Ye, Wen ;

Liu, Jiani ;

Peng, Hui ;

Liu, Ran-Yi ;

Pan, Changchuan ;

Huang, Wenlin .

MOLECULAR CANCER, 2014, 13

[7] Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion [J].

Ni, Qinggan ;

Chen, Jiahui ;

Li, Xia ;

Xu, Xiaodong ;

Zhang, Nannan ;

Zhou, Ang ;

Zhou, Bin ;

Lu, Qian ;

Chen, Zhong .

ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 49 (08) :680-688

[8] NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma [J].

Yang, Huiru ;

Wei, Zhen ;

Song, Yifan ;

Du, Kexin ;

Yin, Nannan ;

Lu, Hong ;

Li, Bingbing ;

Hou, Lili ;

Xing, Panfei ;

Chen, Liang ;

Wang, Chaojie ;

Xie, Songqiang .

CANCER CELL INTERNATIONAL, 2023, 23 (01)

[9] OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer [J].

Yi Zhou ;

Jiangxue Wu ;

Xiang Fu ;

Wuying Du ;

Ling Zhou ;

Xiangqi Meng ;

Hongyan Yu ;

Jiaxin Lin ;

Wen Ye ;

Jiani Liu ;

Hui Peng ;

Ran-yi Liu ;

Changchuan Pan ;

Wenlin Huang .

Molecular Cancer, 13

[10] STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling [J].

Yang, Shuwen ;

Ji, Qinghai ;

Chang, Bin ;

Wang, Yan ;

Zhu, Yongxue ;

Li, Duanshu ;

Huang, Caiping ;

Wang, Yulong ;

Sun, Guohua ;

Zhang, Ling ;

Guan, Qing ;

Xiang, Jun ;

Wei, Wenjun ;

Lu, Zhongwu ;

Liao, Tian ;

Meng, Jiao ;

Wang, Ziliang ;

Ma, Ben ;

Zhou, Li ;

Wang, Yu ;

Yang, Gong .

ONCOTARGET, 2017, 8 (04) :5976-5991

← 1 2 3 4 5 →