OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

被引：83
|
作者：
Zhou, Honghong [1 ,2 ,3 ]
Liu, Yongshuo [1 ,2 ]
Zhu, Rui [1 ,2 ]
Ding, Fang [1 ,2 ]
Cao, Xiufeng [4 ]
Lin, Dongxin [1 ,2 ,3 ]
Liu, Zhihua [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Natl Canc Ctr, Canc Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China
[4] Nanjing Med Univ, Nanjing Hosp 1, Dept Surg Oncol, Nanjing, Jiangsu, Peoples R China
来源：
ONCOGENE | 2018年 / 37卷 / 25期
基金：
国家重点研发计划; 美国国家科学基金会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR SNAIL; BREAST-CANCER; POOR-PROGNOSIS; DEGRADATION; INVASION; EMT; DEUBIQUITINATION; PROGRESSION; ENZYME;
D O I：
10.1038/s41388-018-0224-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Snail is a key regulator of epithelial-mesenchymal transition (EMT) and plays an important role in tumor progression and metastasis. Snail is rapidly degraded in the cells and its protein level is critically controlled. Although several E3 ligases regulating Snail degradation have been defined, the deubiquitinases (DUBs) responsible for Snail deubiquitination are less studied. We identified ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) as a DUB that stabilizes Snail through preventing its ubiquitination and proteasomal degradation. Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability. Moreover, OTUB1 is highly expressed in ESCC and higher expression of OTUB1 predicts poor prognosis. These findings suggest that OTUB1 is an essential regulator of Snail and plays a critical role in facilitating esophageal cancer progression.
引用
收藏
页码：3356 / 3368
页数：13
相关论文
共 50 条
  • [1] OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability
    Honghong Zhou
    Yongshuo Liu
    Rui Zhu
    Fang Ding
    Xiufeng Cao
    Dongxin Lin
    Zhihua Liu
    Oncogene, 2018, 37 : 3356 - 3368
  • [2] Targeting and degradation of OTUB1 by Erianin for antimetastasis in esophageal squamous cell carcinoma
    Zhu, Yuan
    Kang, Ningning
    Zhang, Li
    Tao, Jianju
    Xue, Wen
    Li, Hui
    Li, Yingcan
    Zheng, Xucai
    He, Wei
    Ma, Junting
    PHYTOMEDICINE, 2024, 135
  • [3] USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail
    Li, Lei
    Zhou, Honghong
    Zhu, Rui
    Liu, Zhihua
    CANCER LETTERS, 2019, 448 : 52 - 60
  • [4] EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability
    Guo, Xiaobin
    Zhu, Rui
    Luo, Aiping
    Zhou, Honghong
    Ding, Fang
    Yang, Hongxin
    Liu, Zhihua
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)
  • [5] EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability
    Xiaobin Guo
    Rui Zhu
    Aiping Luo
    Honghong Zhou
    Fang Ding
    Hongxin Yang
    Zhihua Liu
    Journal of Experimental & Clinical Cancer Research, 39
  • [6] Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma
    Zhu, Rui
    Liu, Yongshuo
    Zhou, Honghong
    Li, Lei
    Li, Yi
    Ding, Fang
    Cao, Xiufeng
    Liu, Zhihua
    CANCER LETTERS, 2018, 418 : 125 - 134
  • [7] OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer
    Yi Zhou
    Jiangxue Wu
    Xiang Fu
    Wuying Du
    Ling Zhou
    Xiangqi Meng
    Hongyan Yu
    Jiaxin Lin
    Wen Ye
    Jiani Liu
    Hui Peng
    Ran-yi Liu
    Changchuan Pan
    Wenlin Huang
    Molecular Cancer, 13
  • [8] OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer
    Zhou, Yi
    Wu, Jiangxue
    Fu, Xiang
    Du, Wuying
    Zhou, Ling
    Meng, Xiangqi
    Yu, Hongyan
    Lin, Jiaxin
    Ye, Wen
    Liu, Jiani
    Peng, Hui
    Liu, Ran-Yi
    Pan, Changchuan
    Huang, Wenlin
    MOLECULAR CANCER, 2014, 13
  • [9] Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway
    Li, Qinfang
    Xu, Aiping
    Chu, Yuan
    Chen, Tao
    Li, Hongqi
    Yao, Liqing
    Zhou, Pinghong
    Xu, Meidong
    ONCOLOGY REPORTS, 2019, 42 (05) : 1815 - 1824
  • [10] Endothelin-1 promotes growth and metastasis of esophageal squamous cell carcinoma
    Jayaraman, S.
    Pazhani, J.
    Veeraraghavan, V.
    Roy, J. Rebecca
    Janaki, C.
    Rajagopal, P.
    Prabhu, V.
    ANNALS OF ONCOLOGY, 2023, 34 : S101 - S102
12345