Synthesis, Crystal Structure and Antitumor Activity of a New Trinuclear Ni(II) Complex Ni3(C14H8N3O5)2(C5H5N)4

被引：0

作者：

Qiu Xiao-Yang ^{[1
,2
]}

Xu Mao-Tian ^{[1
]}

Zhu Hai-Liang ^{[2
]}

Liu Wei-Sheng ^{[3
]}

Zhao Wen-Xian ^{[1
]}

机构：

[1] Shangqiu Normal Coll, Dept Chem, Shangqiu 476000, Henan, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2010年 / 26卷 / 02期

关键词：

Ni(II) complex; synthesis; crystal structure; antitumor activity; NICKEL(II) COMPLEXES; IRON CHELATORS; COPPER(II); LIGANDS;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title complex Ni-3(C14H8N3O5)(2)(C5H5N)(4) has been synthesized by the reaction of 2-hydroxy-N'-(4-nitrobenzoyl)benzohydraizide with nickel acetate in pyridine solution. Its molecular structure was characterized by elemental analysis, IR spectra and X-ray crystal structure determination. Crystal data for this compound: Monoclinic, space group P2(1)/c. M-r=1 089.00, a=0.249 27(5) nm, b=0. 16140(3) nm, c=0.12181(2) nm, beta=94.59(3)degrees, V= 4.8852(17) nm(2), Z=4, D-c=1.481 Mg.m(-3). F(000)=2 232, R-1=0.0497, wR(2)=0.1068 (observed reflections with I>2 sigma(I)) and R-1=0. 1051, wR(2)=0. 1194 (all reflections), GOF= 1.021. The complex was evaluated for their antitumor activities against two kinds of cell lines (K562 and BGC) by MTT method. A preliminary bioactivity study indicates that the complex shows distinct antitumor activity. CCDC: 627252.

引用

页码：355 / 359

页数：5

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