An improved method for Lewis acid catalyzed phosphoryl transfer with Ti(t-BuO)4

被引：54

作者：

Jones, S ^{[1
]}

Selitsianos, D ^{[1
]}

Thompson, KJ ^{[1
]}

Toms, SM ^{[1
]}

机构：

[1] Newcastle Univ, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 13期

关键词：

D O I：

10.1021/jo034331g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several inorganic esters have been evaluated as phosphoryl transfer catalysts. Of these, Ti(t-BuO)(4) was found to be the most effective catalyst giving excellent yields of the desired phosphate esters. The loading of the catalyst could be reduced to a little as 5 mol % for a majority of substrates with no loss in the yield of product. This methodology is significantly more versatile than using TiCl4 and is suitable for the phosphorylation of more complex carbohydrates and molecules of biological interest.

引用

页码：5211 / 5216

页数：6

共 23 条

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