Development of an effective contemporary trivalent avian influenza vaccine against circulating H5N1, H5N8, and H9N2 in Egypt

被引：9
|
作者：
Gomaa, Mokhtar Rizk [1 ]
Khalil, Ahmed Ali [2 ]
Kandeil, Ahmed [1 ]
Sabir, Jamal S. M. [3 ,4 ]
Kayed, Ahmed [1 ]
Moatasim, Yassmin [1 ]
El Saied, Marwa F. [5 ]
El-Safty, Mounir M. [5 ]
Kayali, Ghazi [6 ,7 ]
Ali, Mohamed A. [1 ,3 ]
机构：
[1] Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Water Pollut Res Dept, Cairo 12622, Egypt
[2] VSVRI, Cairo 11381, Egypt
[3] King Abdulaziz Univ, Ctr Excellence Bionanosci Res, Jeddah 21589, Saudi Arabia
[4] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Biotechnol Res Grp, Jeddah 21589, Saudi Arabia
[5] Cent Lab Evaluat Vet Biol, Cairo 11381, Egypt
[6] Univ Texas Houston, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA
[7] Human Link, Baabda 1109, Lebanon
来源：
POULTRY SCIENCE | 2019年 / 98卷 / 12期
基金：
美国国家卫生研究院;
关键词：
avian influenza; trivalent; vaccine; Egypt; MULTIPLE INTRODUCTIONS; VIRUSES; POULTRY; OUTBREAKS;
D O I：
10.3382/ps/pez385
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Low pathogenicity avian influenza (LPAI) H9N2, highly pathogenic avian influenza (HPAI) H5N1, and H5N8 circulate in Egyptian poultry and cause veterinary and public health burdens. In response, AIV vaccines are commonly used. The main objective of this study was to develop a broad, cross-protective, trivalent vaccine based on circulating AIVs in Egypt. We generated highly replicating avirulent AIVs, H5N1, and H5N8, to be used in combination with H9N2 strain for the generation of an inactivated vaccine. Immunogenicity and protective efficacy of this vaccine were tested. Results showed that a single immunization dose enhanced humoral immune responses giving full protection against challenges with LPAI H9N2, HPAI H5N1, and H5N8 viruses. This efficacious vaccine will reduce the cost of vaccination for poultry growers and is expected to be effective in the field as it is based on contemporary viruses currently in circulation among Egyptian poultry.
引用
收藏
页码：6289 / 6295
页数：7
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