308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study

被引:55
作者
Le Duff, F. [1 ]
Fontas, E. [3 ]
Giacchero, D. [1 ]
Sillard, L. [1 ]
Lacour, J. -P. [1 ]
Ortonne, J. -P. [1 ]
Passeron, T. [1 ,2 ]
机构
[1] Univ Hosp Nice, Dept Dermatol, F-06200 Nice, France
[2] Univ Hosp Nice, INSERM, U895, Team 1, F-06200 Nice, France
[3] Univ Hosp Nice, Dept Clin Res, F-06200 Nice, France
关键词
308-nm excimer lamp; 308-nm excimer laser; phototherapy; vitiligo; NM; LIGHT; PHOTOTHERAPY; GENETICS; DISEASES;
D O I
10.1111/j.1365-2133.2010.09778.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
P>Background The 308-nm excimer laser and 308-nm excimer lamp have both been shown to be effective in treating vitiligo but a direct comparison has never been performed. Objectives To test the equivalence of these two devices for treating nonsegmental vitiligo. Patients and methods A randomized monocentric study was undertaken. One lesion was treated with the 308-nm excimer laser and its counterpart with the 308-nm excimer lamp. Lesions were treated twice weekly with the same dose on both sides for a total of 24 sessions. The evaluation was done by two independent physicians blinded to the treatment on direct light and ultraviolet light photos. Results Twenty patients were included: 17 completed the study and 104 lesions were treated. The two treatments showed similar results in terms of efficacy for a repigmentation of at least 50% (P = 0 center dot 006). The lamp induced more erythema than the laser. Conclusions The 308-nm excimer lamp and laser showed a similar efficacy in treating vitiligo. For the same fluence, the lamp induced more erythema suggesting photobiological differences between the two devices.
引用
收藏
页码:188 / 192
页数:5
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