The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis

被引:65
作者
Kroon, F. P. B. [1 ]
Veenbrink, A., I [2 ]
de Mutsert, R. [3 ]
Visser, A. W. [1 ]
van Dijk, K. W. [4 ,5 ]
le Cessie, S. [3 ,6 ]
Rosendaal, F. R. [3 ]
Kloppenburg, M. [1 ,3 ]
机构
[1] LUMC, Dept Rheumatol, POB 9600, NL-2300 RC Leiden, Netherlands
[2] Med Spectrum Twente, Dept Internal Med, Twente, Netherlands
[3] LUMC, Dept Clin Epidemiol, Leiden, Netherlands
[4] LUMC, Dept Internal Med, Leiden, Netherlands
[5] LUMC, Dept Human Genet, Leiden, Netherlands
[6] LUMC, Dept Biomed Data Sci, Leiden, Netherlands
关键词
Osteoarthritis; Adipokines; Obesity; Mediation analysis; METABOLIC SYNDROME; SYNOVIAL-FLUID; ADIPOKINES; ASSOCIATION; CLASSIFICATION; INFLAMMATION; PROGRESSION; CRITERIA; OBESITY; WEIGHT;
D O I
10.1016/j.joca.2019.08.003
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Objectives: To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis. Methods: This is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity study. Adiposity was assessed with body mass index (BMI) and percentage total body fat (%TBF). Osteoarthritis, defined as hand or knee osteoarthritis, was determined using American College of Rheumatology criteria. Fasting serum adipokine levels were measured using immunoassays. Associations between adiposity and osteoarthritis were examined with logistic regression, adjusted for age, sex, ethnicity and education, and additionally for leptin and adiponectin as potential mediators. Results: In 6408 participants (56% women, median age 56 years), prevalence of osteoarthritis was 22% (10% isolated knee and 8% isolated hand osteoarthritis). Leptin levels were positively associated with osteoarthritis, while adiponectin levels were not. Leptin partially mediated the association of adiposity with osteoarthritis (OR 1.40 (95%CI 1.30; 1.52) attenuated to 1.38 (1.24; 1.54) per 5 units BMI and OR 1.25 (1.17; 1.35) to 1.20 (1.10; 1.32) per 5 units %TBF, representing 4% and 17% mediation, respectively). Larger proportion mediation by leptin was found in knee (13%/27%) than in hand osteoarthritis (9%/18%). Sex-stratified analyses generally showed stronger associations between adiposity, leptin and osteoarthritis in women than in men. Conclusions: Serum leptin levels were associated with osteoarthritis, and partially mediated the association between adiposity and osteoarthritis, while adiponectin levels were not associated with osteoarthritis. These findings provide evidence for systemic effects of adipose tissue in osteoarthritis. (C) 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1761 / 1767
页数:7
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