NETosis in Neonates: Evidence of a Reactive Oxygen Species-Independent Pathway in Response to Fungal Challenge

被引：30

作者：

Byrd, Angel S. ^{[1
,2
,3
,4
]}

O'Brien, Xian M. ^{[1
]}

Laforce-Nesbitt, Sonia S. ^{[4
]}

Parisi, Valentina E. ^{[1
]}

Hirakawa, Matthew P. ^{[2
,3
]}

Bliss, Joseph M. ^{[2
,3
,4
]}

Reichner, Jonathan S. ^{[1
,2
,3
]}

机构：

[1] Rhode Isl Hosp, Dept Surg, Div Surg Res, Providence, RI USA

[2] Warren Alpert Med Sch, Providence, RI USA

[3] Brown Univ, Grad Program Pathobiol, Providence, RI 02912 USA

[4] Women & Infants Hosp Rhode Isl, Dept Pediat, Providence, RI 02908 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 04期

基金：

美国国家卫生研究院;

关键词：

neonates; neutrophils; NETs; glucan; fungi; NEUTROPHIL EXTRACELLULAR TRAPS; INFLAMMATION; CHEMOTAXIS; SEPSIS;

D O I：

10.1093/infdis/jiv435

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Release of neutrophil extracellular traps (NETs) is a significant antimicrobial host defense mechanism in adults. In neonates, fungal sepsis is a frequent cause of morbidity and mortality and may be a consequence of inadequate neutrophil defense functions. Like neutrophils from adult donors, we found that neutrophils from neonates formed robust cellular aggregates and released NETs in response to fungal beta-glucan and Candida albicans hyphae when presented with extracellular matrix. Therefore, in response to fungal stimulation, neonatal neutrophils are capable of NETosis. Neonate susceptibility to fungal infections may not be due to an inability of their neutrophils to produce NETs.

引用

页码：634 / 639

页数：6

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