Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification

被引：57

作者：

Asa, Sylvia L. ^{[1
]}

Mete, Ozgur ^{[2
]}

Cusimano, Michael D. ^{[3
]}

McCutcheon, Ian E. ^{[4
]}

Perry, Arie ^{[5
]}

Yamada, Shozo ^{[6
]}

Nishioka, Hiroshi ^{[7
]}

Casar-Borota, Olivera ^{[8
]}

Uccella, Silvia ^{[9
]}

La Rosa, Stefano ^{[10
,11
]}

Grossman, Ashley B. ^{[12
,13
,14
,15
]}

Ezzat, Shereen ^{[16
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Dept Pathol, Cleveland, OH 44106 USA

[2] Univ Toronto, Univ Hlth Network, Dept Pathol, Toronto, ON, Canada

[3] Univ Toronto, Dept Neurosurg, St Michaels Hosp, Toronto, ON, Canada

[4] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[5] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[6] Moriyama Neurol Ctr Hosp, Hypothalam & Pituitary Ctr, Tokyo, Japan

[7] Toranomon Gen Hosp, Dept Hypothalam & Pituitary Surg, Tokyo, Japan

[8] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden

[9] Univ Insubria, Dept Pathol, Varese, Italy

[10] Univ Hosp, Inst Pathol, Lausanne, Switzerland

[11] Univ Lausanne, Lausanne, Switzerland

[12] Univ Oxford, Dept Endocrinol, London, England

[13] Royal Free London, London, England

[14] Barts & London Queen Marys Sch Med & Dent, London, England

[15] London Clin Ctr Endocrinol, London, England

[16] Univ Toronto, Univ Hlth Network, Dept Med, Toronto, ON, Canada

来源：

MODERN PATHOLOGY | 2021年 / 34卷 / 09期

关键词：

ENDOCRINE NEOPLASIA TYPE-1; PROGNOSTIC CLINICOPATHOLOGICAL CLASSIFICATION; RECEPTOR-INTERACTING-PROTEIN; STEM-CELL ADENOMA; LONG-TERM CURE; TRANSSPHENOIDAL SURGERY; CUSHINGS-DISEASE; NULL-CELL; FOLLOW-UP; CLINICAL CHARACTERISTICS;

D O I：

10.1038/s41379-021-00820-y

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The classification of adenohypophysial neoplasms as "pituitary neuroendocrine tumors" (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified approach to neuroendocrine neoplasia in all body sites. We review the features that are characteristic of neuroendocrine cells, the epidemiology and prognosis of these tumors, as well as further refinements in terms used for other pituitary tumors to ensure consistency with the WHO framework. The intense study of PitNETs has provided information about the importance of cellular differentiation in tumor prognosis as a model for neuroendocrine tumors in different locations.

引用

页码：1634 / 1650

页数：17

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