Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice

被引:13
|
作者
Dai, Chongshan [1 ]
Tang, Shusheng [1 ]
Li, Jichang [2 ]
Wang, Jiping [3 ]
Xiao, Xilong [1 ]
机构
[1] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
[2] Northeast Agr Univ, Coll Vet Med, Harbin, Peoples R China
[3] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia
关键词
CRITICALLY-ILL PATIENTS; NEGATIVE BACTERIAL-INFECTIONS; POPULATION PHARMACOKINETICS; PSEUDOMONAS-AERUGINOSA; INTRAVENOUS COLISTIN; DOSAGE REGIMENS; TOXICITY; METHANESULFONATE; POLYMYXINS; NEUROPHYSIOLOGY;
D O I
10.1111/bcpt.12272
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of this study was to examine the changes of sensory nerve conduction velocity (SNCV) and F-wave for colistin-induced peripheral neurotoxicity using a mouse model. Mice were administered with colistin 5, 7.5 and 15mg/kg/day via a 3-min. intravenous infusion. The sensory nerve conduction velocity (SNCV) and F-wave were measured using the bipolar recording electrodes. The SNCV and F-wave latency changed in a dose- and time-dependent manner. The significant increase of F-wave latency and significant decrease of SNCV appeared on day 3 (p<0.05 and 0.01, respectively) in the 15mg/kg/day group, and they were markedly changed on day 7 in the 7.5mg/kg/day (p<0.01 and 0.05, respectively) and 15mg/kg/day groups (both p<0.01). In addition, F-wave latency also significantly increased on day 7 in the 5mg/kg/day group (p<0.05) without any clinical signs. These results indicate that SNCV and F-wave latency were more sensitive in colistin-induced neurotoxicity in mice, which highlights the early monitoring tool of polymyxins neurotoxicity in the clinic.
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页码:577 / 580
页数:4
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