PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2

被引：23

作者：

Simon, Viviana ^{[1
,2
,3
,19
,20
]}

Kota, Vamsi ^{[10
]}

Bloomquist, Ryan F. ^{[11
]}

Hanley, Hannah B. ^{[4
]}

Forgacs, David ^{[4
]}

Pahwa, Savita ^{[12
]}

Pallikkuth, Suresh ^{[12
]}

Miller, Loren G. ^{[6
,7
]}

Schaenman, Joanna ^{[6
]}

Yeaman, Michael R. ^{[6
,7
]}

Manthei, David ^{[16
]}

Wolf, Joshua ^{[18
]}

Gaur, Aditya H. ^{[18
]}

Estepp, Jeremie H. ^{[18
]}

Srivastava, Komal ^{[1
]}

Carreno, Juan Manuel ^{[1
]}

Cuevas, Frans ^{[1
]}

Ellebedy, Ali H. ^{[13
,14
,15
]}

Gordon, Aubree ^{[16
]}

Valdez, Riccardo ^{[21
]}

Cobey, Sarah ^{[17
]}

Reed, Elaine F. ^{[8
]}

Kolhe, Ravindra ^{[9
,10
,11
]}

Thomas, Paul G. ^{[18
]}

Schultz-Cherry, Stacey ^{[18
]}

Ross, Ted M. ^{[4
,5
]}

Krammer, Florian ^{[1
,19
,20
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY USA

[3] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY USA

[4] Univ Georgia, Ctr Vaccine & Immunol, Athens, GA 30602 USA

[5] Univ Georgia, Dept Infect Dis, Athens, GA 30602 USA

[6] UCLA, Dept Med, David Geffen Sch Med, Los Angeles, CA USA

[7] Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Torrance, CA USA

[8] UCLA, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA USA

[9] Augusta Univ, Med Coll Georgia, Dept Pathol, Augusta, GA USA

[10] Augusta Univ, Med Coll Georgia, Dept Med, Augusta, GA USA

[11] Augusta Univ, Dent Coll Georgia, Dept Restorat Sci, Augusta, GA USA

[12] Univ Miami, Dept Microbiol & Immunol, Miller Sch Med, Miami, FL USA

[13] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO USA

[14] Washington Univ, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, Sch Med, St Louis, MO USA

[15] Washington Univ, Ctr Vaccines & Immun Microbial Pathogens, Sch Med, St Louis, MO USA

[16] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[17] Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA

[18] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN USA

[19] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, New York, NY 10029 USA

[20] Icahn Sch Med Mt Sinai, Ctr Vaccine Res & Pandem Preparedness C VARPP, New York, NY 10029 USA

[21] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

MSPHERE | 2022年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

COVID-19; SARS-CoV-2; antibodies; cohort study; reinfection; REINFECTION; RESPONSES; INFLUENZA;

D O I：

10.1128/msphere.00179-22

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world. Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

引用

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