Zinc deficiency: An unexpected trigger for autophagy

被引：21

作者：

Ding, Binbin ^{[1
]}

Zhong, Qing ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dept Internal Med, Ctr Autophagy Res, Dallas, TX 75390 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 20期

关键词：

BREAST-CANCER; DEATH;

D O I：

10.1074/jbc.H116.762948

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells respond to deprivation of certain nutrients such as glucose or nitrogen by inducing autophagy, reclaiming pieces of proteins for use in critical functions. A recent study shows that, in yeast, zinc depletion acts in a similar fashion. Depletion of this essential nutrient induces non-selective autophagy by inhibiting TORC1, leading to release and recycling of zinc from degraded proteins.

引用

页码：8531 / 8532

页数：2

共 8 条

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