Effect of citrus pectin on malignant cell proliferation

被引：47

作者：

Bergman, M. ^{[2
]}

Djaldetti, M. ^{[1
,3
]}

Salman, H. ^{[2
]}

Bessler, H. ^{[1
,3
]}

机构：

[1] Hasharon Hosp, Lab Immunol & Hematol Res, Rabin Med Ctr, IL-49372 Petah Tiqwa, Israel

[2] Hasharon Hosp, Dept Med C, Rabin Med Ctr, IL-49372 Petah Tiqwa, Israel

[3] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2010年 / 64卷 / 01期

关键词：

Citrus pectin; Malignant cells; Cell proliferation; RAT COLON CARCINOGENESIS; GALECTINS-1; AND-3; APPLE PECTIN; IN-VITRO; CANCER; METASTASIS; EXPRESSION; INHIBITION; APOPTOSIS; LYMPHOMAS;

D O I：

10.1016/j.biopha.2009.03.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of citrus pectin (CP) on the proliferative capacity of four malignant cell lines was examined. Various dose of CP inhibited the proliferation of two-colon carcinoma and an erythroleukemia cell lines. Raji cells were not affected at all. The three lines affected by CP are known to express galectins which are pivotal for cell growth and metastasis, while Raji cells, whose proliferation was not affected by CP, are deficient of this betagalactoside. It is possible that the antiproliferative effect of CP on the malignant cells may be due at least in part to its ability to inhibit galectin expression. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：44 / 47

页数：4

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