Effect of citrus pectin on malignant cell proliferation

被引：49

作者：

Bergman, M. ^{[2
]}

Djaldetti, M. ^{[1
,3
]}

Salman, H. ^{[2
]}

Bessler, H. ^{[1
,3
]}

机构：

[1] Hasharon Hosp, Lab Immunol & Hematol Res, Rabin Med Ctr, IL-49372 Petah Tiqwa, Israel

[2] Hasharon Hosp, Dept Med C, Rabin Med Ctr, IL-49372 Petah Tiqwa, Israel

[3] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2010年 / 64卷 / 01期

关键词：

Citrus pectin; Malignant cells; Cell proliferation; RAT COLON CARCINOGENESIS; GALECTINS-1; AND-3; APPLE PECTIN; IN-VITRO; CANCER; METASTASIS; EXPRESSION; INHIBITION; APOPTOSIS; LYMPHOMAS;

D O I：

10.1016/j.biopha.2009.03.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of citrus pectin (CP) on the proliferative capacity of four malignant cell lines was examined. Various dose of CP inhibited the proliferation of two-colon carcinoma and an erythroleukemia cell lines. Raji cells were not affected at all. The three lines affected by CP are known to express galectins which are pivotal for cell growth and metastasis, while Raji cells, whose proliferation was not affected by CP, are deficient of this betagalactoside. It is possible that the antiproliferative effect of CP on the malignant cells may be due at least in part to its ability to inhibit galectin expression. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：44 / 47

页数：4

共 24 条

[1] Human galectin-8 isoforms and cancer [J].

Bidon-Wagner, N ;

Le Pennec, JP .

GLYCOCONJUGATE JOURNAL, 2002, 19 (7-9) :557-563

[2] Phytochemicals: Guardians of our health (Reprinted from Issues in Vegetarian Dietetics, vol 5, pg 1-8, 1996) [J].

Craig, WJ .

JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1997, 97 (10) :S199-S204

[3] The differential expression of galectin-1 and galectin-3 in normal lymphoid tissue and non-Hodgkin's and Hodgkin's lymphomas [J].

D'Haene, N ;

Maris, C ;

Sandras, F ;

Dehou, MF ;

Remmelink, M ;

Decaestecker, C ;

Salmon, I .

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2005, 18 (03) :431-443

[4] Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs [J].

Glinskii, OV ;

Huxley, VH ;

Glinsky, GV ;

Pienta, KJ ;

Raz, A ;

Glinsky, VV .

NEOPLASIA, 2005, 7 (05) :522-527

[5] Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions [J].

Greco, C ;

Vona, R ;

Cosimelli, M ;

Matarrese, P ;

Straface, E ;

Scordati, P ;

Giannarelli, D ;

Casale, V ;

Assisi, D ;

Mottolese, M ;

Moles, A ;

Malorni, W .

GLYCOBIOLOGY, 2004, 14 (09) :783-792

[6] Upregulation of galectins-1 and-3 in human colon cancer and their role in regulating cell migration [J].

Hittelet, A ;

Legendre, H ;

Nagy, N ;

Bronckart, Y ;

Pector, JC ;

Salmon, I ;

Yeaton, P ;

Gabius, HJ ;

Kiss, R ;

Camby, I .

INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (03) :370-379

[7] An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas [J].

Hoyer, KK ;

Pang, M ;

Gui, D ;

Shintaku, IP ;

Kuwabara, I ;

Liu, FT ;

Said, JW ;

Baum, LG ;

Teitell, MA .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (03) :893-902

[8]

Huang Zhi-liang, 2008, Nan Fang Yi Ke Da Xue Xue Bao, V28, P1358

[9] EFFECTS OF NATURAL COMPLEX CARBOHYDRATE (CITRUS PECTIN) ON MURINE MELANOMA CELL PROPERTIES RELATED TO GALECTIN-3 FUNCTIONS [J].

INOHARA, H ;

RAZ, A .

GLYCOCONJUGATE JOURNAL, 1994, 11 (06) :527-532

[10] Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure [J].

Jackson, Crystal L. ;

Dreaden, Tina M. ;

Theobald, Lisa K. ;

Tran, Nhien M. ;

Beal, Tiffany L. ;

Eid, Manal ;

Gao, Mu Yun ;

Shirley, Robert B. ;

Stoffel, Mark T. ;

Kumar, M. Vijay ;

Mohnen, Debra .

GLYCOBIOLOGY, 2007, 17 (08) :805-819

← 1 2 3 →