Evolution of treatment targets in Crohn's disease

被引：4
作者：
White, Jonathan R. [1 ,2 ,3 ]
Jairath, Vipul [4 ,5 ]
Moran, Gordon W. [1 ,2 ,3 ]
机构：
[1] Nottingham Univ Hosp NHS Trust, Nottingham Biomed Res Ctr, Natl Inst Hlth Res, Nottingham, England
[2] Univ Nottingham, Nottingham, England
[3] Univ Nottingham, Nottingham Digest Dis Ctr, Nottingham, England
[4] Western Univ, Div Gastroenterol, Dept Med, London, ON, Canada
[5] Western Univ, Dept Epidemiol & Biostat, London, ON, Canada
来源：
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2019年 / 38-39卷
关键词：
Crohn's disease; Treatment targets; Patient reported outcomes; Clinician reported activity indices; Biomarkers; Endoscopy; Imaging; Histology; INFLAMMATORY-BOWEL-DISEASE; PATIENT-REPORTED OUTCOMES; C-REACTIVE PROTEIN; POST-HOC ANALYSIS; QUALITY-OF-LIFE; FECAL CALPROTECTIN; ULCERATIVE-COLITIS; ACTIVITY INDEX; LEMANN INDEX; MAINTENANCE THERAPY;
D O I：
10.1016/j.bpg.2019.02.001
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Crohn's disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient's quality of life. An early treat to target approach with disease modifying agents has been shown to significantly improve long term outcomes, demonstrated by a number of therapeutic targets in a number of modalities. This review will outline the current treatment targets and measures of disease burden in Crohn's disease. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：9
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