Surgical materials: Current challenges and nano-enabled solutions

被引:179
作者
Annabi, Nasim [1 ,2 ,3 ]
Tamayol, Ali [1 ,2 ]
Shin, Su Ryon [1 ,2 ,3 ]
Ghaemmaghami, Amir M. [4 ]
Peppas, Nicholas A. [5 ,6 ]
Khademhosseini, Ali [1 ,2 ,3 ,5 ,6 ,7 ,8 ,9 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Biomat Innovat,Dept Med, Boston, MA 02115 USA
[2] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[4] Univ Nottingham, Fac Med & Hlth Sci, Sch Life Sci, Div Immunol, Nottingham NG7 2RD, England
[5] Univ Texas Austin, Dept Chem Engn, Dept Biomed Engn, Austin, TX 78712 USA
[6] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA
[7] Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
[8] Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South Korea
[9] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia
基金
美国国家科学基金会; 英国医学研究理事会; 美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词
Nano-enabled surgical materials; Sealants; Tissue adhesives; Hemostatic agents; Antibacterial bioadhesives; AMORPHOUS CALCIUM-PHOSPHATE; CANINE ABDOMINOPLASTY MODEL; DRUG-DELIVERY SYSTEMS; TISSUE ADHESIVE; FIBRIN SEALANT; IN-VITRO; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; HEMOSTATIC AGENTS; CARDIAC-SURGERY;
D O I
10.1016/j.nantod.2014.09.006
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:574 / 589
页数:16
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