Cu-catalysed transamidation of unactivated aliphatic amides

被引：11

作者：

Kumar, Vishal ^{[1
]}

Dhawan, Sanjeev ^{[1
]}

Bala, Renu ^{[1
]}

Mohite, Sachin Balaso ^{[1
]}

Singh, Parvesh ^{[2
]}

Karpoormath, Rajshekhar ^{[1
]}

机构：

[1] Univ KwaZulu Natal Westville, Coll Hlth Sci, Dept Pharmaceut Chem, Discipline Pharmaceut Sci, ZA-4000 Durban, South Africa

[2] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Private Bag X, Durban, South Africa

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 34期

基金：

新加坡国家研究基金会;

关键词：

CARBOXAMIDES; ACTIVATION; CLEAVAGE;

D O I：

10.1039/d2ob01152b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct transamidation is gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, has been a long-standing issue in comparison to transamidation of activated amides. Herein, we report a transamidation approach of an unactivated aliphatic amide using a copper catalyst and chlorotrimethylsilane as an additive. In addition, we used transamidation as a tool for selective N-C(O) cleavage and O-C(O) formation to synthesise 2-substituted benzoxazoles and benzothiazoles. The reactions were carried out without using any solvents and offered wide substitution scope.

引用

页码：6931 / 6940

页数：10

共 55 条

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