Facing up to the global challenges of ageing

被引：820

作者：

Partridge, Linda ^{[1
,2
,3
]}

Deelen, Joris ^{[1
,4
]}

Slagboom, P. Eline ^{[1
,4
]}

机构：

[1] Max Planck Inst Biol Ageing, Cologne, Germany

[2] UCL, Inst Hlth Ageing, London, England

[3] UCL, Dept Genet Evolut & Environm, London, England

[4] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, Leiden, Netherlands

来源：

NATURE | 2018年 / 561卷 / 7721期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; ADVERSE DRUG-REACTIONS; LIFE-SPAN; CALORIE RESTRICTION; CELLULAR SENESCENCE; HUMAN LONGEVITY; CARDIOVASCULAR-DISEASE; DIETARY RESTRICTION; POPULATION HEALTH; GUT MICROBIOTA;

D O I：

10.1038/s41586-018-0457-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.

引用

页码：45 / 56

页数：12

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