Hypersensitivity reactions and anaphylaxis to checkpoint inhibitor- monoclonal antibodies and desensitization

被引：15

作者：

Labella, Marina ^{[1
,2
]}

Castells, Mariana ^{[3
]}

机构：

[1] Hosp Reg Univ Malaga, Allergy Clin Unit, Plaza Hosp Civil S-N, Malaga 29009, Spain

[2] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2021年 / 126卷 / 06期

关键词：

BASOPHIL ACTIVATION TEST; DRUG HYPERSENSITIVITY; PRACTICAL GUIDANCE; RAPID DESENSITIZATION; MANAGEMENT; DIAGNOSIS; ALLERGY; CANCER; RISK;

D O I：

10.1016/j.anai.2021.03.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective: To review type 1 hypersensitivity reactions and anaphylaxis to checkpoint inhibitor-monoclonal antibodies and its management with drug desensitization. Data Sources: English-language literature on MEDLINE regarding hypersensitivity, anaphylaxis, and checkpoint inhibitor-monoclonal antibodies. Study Selections: References were selected based on relevance, novelty, robustness, and applicability. Results: There are well-known tissue toxicities associated to checkpoint inhibitors, but hypersensitivity reactions and anaphylaxis have been underreported. The presentation of these reactions is based on clinical phenotypes with underlying endotypes identified by specific biomarkers. Drug desensitizations have been successfully applied to checkpoint inhibitor drugs to allow patients with cancer to receive first-line therapies. This review provides current best practices for the recognition and diagnosis of hypersensitivity reactions and anaphylaxis to checkpoint inhibitors and their management using drug desensitization. Conclusion: Hypersensitivity reactions and anaphylaxis have been identified as potential adverse effects induced by checkpoint inhibitor-monoclonal antibodies. Drug desensitization is a safe and effective treatment option for patients who experience hypersensitivity reactions in need of these monoclonal antibodies to improve cancer outcomes. (c) 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

引用

页码：623 / 629

页数：7

共 57 条

[1] Evaluation of Immunogenicity of Nivolumab Monotherapy and Its Clinical Relevance in PatientsWith Metastatic Solid Tumors [J].

Agrawal, Shruti ;

Statkevich, Paul ;

Bajaj, Gaurav ;

Feng, Yan ;

Saeger, Sally ;

Desai, Dharmesh D. ;

Park, Jong-Soon ;

Waxman, Ian M. ;

Roy, Amit ;

Gupta, Manish .

JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 57 (03) :394-400

[2] Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens A Systematic Review and Meta-analysis [J].

Barroso-Sousa, Romualdo ;

Barry, William T. ;

Garrido-Castro, Ana C. ;

Hodi, F. Stephen ;

Min, Le ;

Krop, Ian E. ;

Tolaney, Sara M. .

JAMA ONCOLOGY, 2018, 4 (02) :173-182

[3] Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [J].

Brahmer, Julie R. ;

Lacchetti, Christina ;

Schneider, Bryan J. ;

Atkins, Michael B. ;

Brassil, Kelly J. ;

Caterino, Jeffrey M. ;

Chau, Ian ;

Ernstoff, Marc S. ;

Gardner, Jennifer M. ;

Ginex, Pamela ;

Hallmeyer, Sigrun ;

Chakrabarty, Jennifer Holter ;

Leighl, Natasha B. ;

Mammen, Jennifer S. ;

McDermott, David F. ;

Naing, Aung ;

Nastoupil, Loretta J. ;

Phillips, Tanyanika ;

Porter, Laura D. ;

Puzanov, Igor ;

Reichner, Cristina A. ;

Santomasso, Bianca D. ;

Seigel, Carole ;

Spira, Alexander ;

Suarez-Almazor, Maria E. ;

Wang, Yinghong ;

Weber, Jeffrey S. ;

Wolchok, Jedd D. ;

Thompson, John A. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) :1714-+

[4] Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs [J].

Broyles, Ana Dioun ;

Banerji, Aleena ;

Barmettler, Sara ;

Biggs, Catherine M. ;

Blumenthal, Kimberly ;

Brennan, Patrick J. ;

Breslow, Rebecca G. ;

Brockow, Knut ;

Buchheit, Kathleen M. ;

Cahill, Katherine N. ;

Cernadas, Josefina ;

Chiriac, Anca Mirela ;

Crestani, Elena ;

Demoly, Pascal ;

Dewachter, Pascale ;

Dilley, Meredith ;

Farmer, Jocelyn R. ;

Foer, Dinah ;

Fried, Ari J. ;

Garon, Sarah L. ;

Giannetti, Matthew P. ;

Hepner, David L. ;

Hong, David I. ;

Hsu, Joyce T. ;

Kothari, Parul H. ;

Kyin, Timothy ;

Lax, Timothy ;

Lee, Min Jung ;

Lee-Sarwar, Kathleen ;

Liu, Anne ;

Logsdon, Stephanie ;

Louisias, Margee ;

MacGinnitie, Andrew ;

Maciag, Michelle ;

Minnicozzi, Samantha ;

Norton, Allison E. ;

Otani, Iris M. ;

Park, Miguel ;

Patil, Sarita ;

Phillips, Elizabeth J. ;

Picard, Matthieu ;

Platt, Craig D. ;

Rachid, Rima ;

Rodriguez, Tito ;

Romano, Antonino ;

Stone, Cosby A., Jr. ;

Torres, Maria Jose ;

Verdu, Miriam ;

Wang, Alberta L. ;

Wickner, Paige .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2020, 8 (09) :S16-S116

[5]

Broyles AD, 2020, J ALLER CL IMM-PRACT, V8, pS3, DOI [10.1016/j.jaip.2020.08.002, 10.1016/j.jaip.2010.08.002]

[6] Immediate Hypersensitivity Reactions Caused by Drug Excipients: A Literature Review [J].

Caballero, M. L. ;

Quirce, S. .

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2020, 30 (02) :86-100

[7] Rapid desensitization to antineoplastic drugs in an outpatient immunoallergology clinic Outcomes and risk factors [J].

Caiado, Joana ;

Bras, Rita ;

Paulino, Marisa ;

Costa, Luis ;

Castells, Mariana .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2020, 125 (03) :325-+

[8] Presentation and Diagnosis of Hypersensitivity to Platinum Drugs [J].

Caiado, Joana ;

Castells, Mariana .

CURRENT ALLERGY AND ASTHMA REPORTS, 2015, 15 (04)

[9] Update on Desensitization [J].

Campos, Lucila ;

Hamadi, Sahar A. ;

Lynch, Donna-Marie ;

Marquis, Kathleen ;

Castells, Mariana C. .

CURRENT TREATMENT OPTIONS IN ALLERGY, 2019, 6 (04) :519-537

[10] BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice? [J].

Campos, Lucila ;

Galvao, Violeta Regnier ;

Kalil, Jorge ;

Castells, Mariana ;

Giavina-Bianchi, Pedro .

CURRENT ALLERGY AND ASTHMA REPORTS, 2019, 19 (04)

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