Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages

被引：15

作者：

Choi, Mijoo ^{[1
]}

Lee, Yunjung ^{[1
]}

Lee, Na-Kyoung ^{[2
]}

Bae, Chun Ho ^{[3
]}

Park, Dae Chul ^{[3
]}

Paik, Hyun-Dong ^{[2
]}

Park, Eunju ^{[1
]}

机构：

[1] Kyungnam Univ, Dept Food & Nutr, Chang Won 51767, South Korea

[2] Konkuk Univ, Dept Food Sci & Biotechnol Anim Resource, Seoul 05029, South Korea

[3] Aram Co Ltd, Gwangju Si 12735, Gyeonggi Do, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2019年 / 29卷 / 11期

关键词：

Bifidobacterium longum KACC 91563; cytokine; immunomodulatory effect; Th1/Th2; balance; B-CELLS; MODULATION; SUPPRESSION; ACTIVATION; PROBIOTICS; ANTIGENS; EXTRACT; KIMCHI; MICE; TH17;

D O I：

10.4014/jmb.1812.12002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated T-and B-cell proliferation and inhibited the Th1 (IL-2, IFN-gamma)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.

引用

页码：1739 / 1744

页数：6

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