Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy

被引：28

作者：

Zhao, Jiawei ^{[1
,2
]}

Li, Yue ^{[1
,3
]}

Jia, Rongrong ^{[1
]}

Wang, Jinghui ^{[1
]}

Shi, Min ^{[1
]}

Wang, Yugang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, Shanghai, Peoples R China

[2] Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

mesenchymal stem cells; exosomes; dexamethasone; autoimmune hepatitis; delivery;

D O I：

10.3389/fbioe.2021.650376

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed that Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of Exos is confirmed, and dexamethasone (DEX)-incorporated Exos named Exo@DEX are prepared. It is then investigated whether Exo@DEX can function more efficiently compared to free drugs and naive Exos in a Con A-induced autoimmune hepatitis (AIH) mouse model. The results show that Exo@DEX efficiently improves the accumulation of DEX in AIH in the liver. These data suggest that Exo@DEX is a promising drug carrier for AIH and could have applications in other diseases.

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