Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

被引：17

作者：

Magallon, Maria ^{[1
,2
]}

Carrion, Ana Esther ^{[1
,2
]}

Banuls, Lucia ^{[1
,2
]}

Pellicer, Daniel ^{[1
,2
]}

Castillo, Silvia ^{[2
,3
]}

Bondia, Sergio ^{[2
]}

Navarro-Garcia, Maria Mercedes ^{[2
]}

Gonzalez, Cruz ^{[2
,4
]}

Dasi, Francisco ^{[1
,2
]}

机构：

[1] Univ Valencia, Dept Physiol, Sch Med, Res Grp Rare Resp Dis ERR, Avda Blasco Ibanez 15, Valencia 46010, Spain

[2] Fdn Invest Hosp Clin Valencia, Inst Invest Sanitaria INCLIVA, Res Grp Rare Resp Dis ERR, Avda Menendez y Pelayo 4, Valencia 46010, Spain

[3] Hosp Clin Univ Valencia, Paediat Unit, Avda Blasco Ibanez 17, Valencia 46010, Spain

[4] Hosp Clin Univ Valencia, Pneumol Unit, Avda Blasco Ibanez 17, Valencia 46010, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 06期

关键词：

oxidative stress; endoplasmic reticulum stress; antioxidant therapies; rare respiratory diseases; Alpha-1 antitrypsin deficiency; idiopathic pulmonary fibrosis; cystic fibrosis; primary ciliary dyskinesia; NF-KAPPA-B; IDIOPATHIC PULMONARY-FIBROSIS; PRIMARY CILIARY DYSKINESIA; EPITHELIAL-MESENCHYMAL TRANSITION; CYSTIC-FIBROSIS; UNFOLDED-PROTEIN; ER STRESS; TRANSCRIPTION FACTOR; NITRIC-OXIDE; BRONCHOALVEOLAR LAVAGE;

D O I：

10.3390/jcm10061268

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

引用

页码：1 / 27

页数：25

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