Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways

被引：89

作者：

Kang, Changkeun ^{[1
]}

Jin, Yeung Bae ^{[2
]}

Lee, Hyunkyoung ^{[1
]}

Cha, Mijin ^{[1
]}

Sohn, Eun-tae ^{[1
]}

Moon, Jonghyun ^{[1
]}

Park, Cholwoo ^{[1
]}

Chun, Soohee ^{[1
]}

Jung, Eun-Sun ^{[1
]}

Hong, Jeong-Sook ^{[3
]}

Kim, Soon Bok ^{[2
]}

Kim, Jong-Shu ^{[1
]}

Kim, Euikyung ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Coll Vet Med, Dept Pharmacol & Toxicol, Jinju 660701, South Korea

[2] Gyeongsang Natl Univ, Coll Vet Med, Dept Pathol, Jinju 660701, South Korea

[3] Jinju Gospel Hosp, Dept Anesthesia, Jinju, Gyeongsangnam D, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 02期

关键词：

Brown alga; Ecklonto cava; Methanol extract; Polyphenol; Diabetes mellitus; OXIDATIVE STRESS; GREEN TEA; ANTIOXIDANT PROPERTIES; POLYPHENOLS; GLUCOSE; PHLOROTANNINS; EXTRACTS; ATHEROSCLEROSIS; SUPPLEMENTATION; PATHOGENESIS;

D O I：

10.1016/j.fct.2009.11.004

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The antidiabetic therapeutic effect of Ecklonia cava, a brown alga, was investigated using streptozotocin-induced type I diabetes mellitus rats and C2C12 myoblasts. The methanol extract of E cava (ECM), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats. Moreover, the elevation of plasma ALT in diabetic rats was dramatically restored near to normal range by the treatment of ECM, whereas AST level was not meaningfully altered in any group throughout the experiment. The characteristic indications of diabetes, such as polyphagia and polydipsia, were greatly improved by ECM treatment as well. The mechanism of action of ECM appears to be, at least partially, mediated by the activation of both AMP-activated protein kinase/ACC and PI-3 kinase/Akt signal pathways Taken together, the present results suggest that E. cava has both in vivo and in vitro antidiabetic effects (C) 2009 Elsevier Ltd. All rights reserved

引用

页码：509 / 516

页数：8

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