Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection

被引：23

作者：

Coppola, Nicola

Genovese, Domenico

Pisaturo, Mariantonietta

Taffon, Stefania

Argentini, Claudio

Pasquale, Giuseppe

Sagnelli, Caterina

Piccinino, Felice

Rapicetta, Maria

Sagnelli, Evangelista

机构：

[1] Univ Naples 2, Dept Publ Med, Infect Dis Sect, Osped Gesu & Maria, I-80135 Naples, Italy

[2] Ist Super Sanita, Viral Hepatitis Unit, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 09期

关键词：

D O I：

10.1086/513430

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course. Methods. We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation ( peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months. Results. Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness. Conclusions. Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.

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页码：E73 / E77

页数：5

相关论文

共 24 条

[1] EPIDEMIOLOGIC ASPECTS OF SANTA-MARTA HEPATITIS OVER A 40-YEAR PERIOD [J].

BUITRAGO, B ;

HADLER, SC ;

POPPER, H ;

THUNG, SN ;

GERBER, MA ;

PURCELL, RH ;

MAYNARD, JE .

HEPATOLOGY, 1986, 6 (06) :1292-1296

[2] Genetic analysis of HAV strains recovered from patients with acute hepatitis from southern Italy [J].

Chironna, M ;

Grottola, A ;

Lanave, C ;

Villa, E ;

Barbuti, S ;

Quarto, M .

JOURNAL OF MEDICAL VIROLOGY, 2003, 70 (03) :343-349

[3] COMPLETE NUCLEOTIDE-SEQUENCE OF WILD-TYPE HEPATITIS-A VIRUS - COMPARISON WITH DIFFERENT STRAINS OF HEPATITIS-A VIRUS AND OTHER PICORNAVIRUSES [J].

COHEN, JI ;

TICEHURST, JR ;

PURCELL, RH ;

BUCKLERWHITE, A ;

BAROUDY, BM .

JOURNAL OF VIROLOGY, 1987, 61 (01) :50-59

[4] Acute hepatitis B and C virus coinfection: A virological and clinical study of 3 cases [J].

Coppola, N ;

Marrocco, C ;

Di Caprio, D ;

Coviello, G ;

Scolastico, C ;

Filippini, P ;

Sagnelli, E .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (04) :528-532

[5] Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil [J].

de Paula, VS ;

Baptista, ML ;

Lampe, E ;

Niel, C ;

Gaspar, AMC .

JOURNAL OF MEDICAL VIROLOGY, 2002, 66 (01) :22-27

[6]

Farci P, 2000, SEMIN LIVER DIS, V20, P103

[7] Association between severity of type A hepatitis and nucleotide variations in the 5′ non-translated region of hepatitis A virus RNA:: strains from fulminant hepatitis have fewer nucleotide substitutions [J].

Fujiwara, K ;

Yokosuka, O ;

Ehata, T ;

Saisho, H ;

Saotome, N ;

Suzuki, K ;

Okita, K ;

Kiyosawa, K ;

Omata, M .

GUT, 2002, 51 (01) :82-88

[8] Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis [J].

Fujiwara, K ;

Yokosuka, O ;

Fukai, K ;

Imazeki, F ;

Saisho, H ;

Omata, M .

JOURNAL OF HEPATOLOGY, 2001, 35 (01) :112-119

[9]

HALL T. A., 1999, Nucleic Acids Symp Ser, V41, P95, DOI [10.1021/bk-1999-0734.ch008, DOI 10.1021/BK-1999-0734.CH008]

[10] MEGA2: molecular evolutionary genetics analysis software [J].

Kumar, S ;

Tamura, K ;

Jakobsen, IB ;

Nei, M .

BIOINFORMATICS, 2001, 17 (12) :1244-1245