Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C-H activation: Facile synthesis of benzo[g]indolines

被引：31

作者：

Wang, Lianhui ^{[1
]}

Xiong, Dan ^{[1
]}

Jie, Lianghua ^{[1
]}

Yu, Chudan ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Sch Biomed Sci, Key Lab Xiamen Marine & Gene Drugs, Engn Res Ctr Mol Med,Minist Educ,Key Lab Fujian M, Xiamen 361021, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Rhodium; Indoline; Alkyne; Benzoldindoline; C-H activation; BOND ACTIVATION; CARBAMOYL INDOLINES; SEQUENTIAL CLEAVAGE; EXPEDIENT SYNTHESIS; INTERNAL ALKYNES; ROOM-TEMPERATURE; INDOLES; ANNULATION; FUNCTIONALIZATION; ALKYNYLATION;

D O I：

10.1016/j.cclet.2018.05.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein report a highly regioselective rhodium-catalyzed C6-and C7-H bond functionalization of indolines with alkynes by using 2-pyrimidine as a directing group. Moreover, NH -free benzo[g]indole unit could be obtained by an oxidation/removal of the directing group sequence. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：907 / 910

页数：4

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