Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus

被引：12

作者：

Pranzetti, Alice ^{[1
]}

Davis, Matthew ^{[3
]}

Yeung, Chun L. ^{[1
]}

Preece, Jon A. ^{[2
]}

Koelsch, Patrick ^{[3
]}

Mendes, Paula M. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[3] Univ Washington, Dept Bioengn, Natl ESCA & Surface Anal Ctr Biomed Problems, Seattle, WA 98195 USA

来源：

ADVANCED MATERIALS INTERFACES | 2014年 / 1卷 / 05期

基金：

英国惠康基金;

关键词：

SUM-FREQUENCY-GENERATION; SELF-ASSEMBLED MONOLAYERS; ELECTROCHEMICAL INTERFACE; OLIGO(ETHYLENE GLYCOL); SURFACE; SPECTROSCOPY; FUNCTIONALIZATION; PROTEINS;

D O I：

10.1002/admi.201400026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli. © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页数：4

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