Dietary beta-carotene intake is inversely associated with anxiety in US midlife women

Background: To study the association of beta-carotene intake from diet with anxiety in US midlife women. Methods: Analyses were performed on the baseline data of the Study of Women?s Health Across the Nation (SWAN), a multicenter and population-based study of the natural history of US midlife women aged from 42 to 52. Logistic regression and restricted cubic spline models were performed to examine the association of betacarotene intake with anxiety. Results: A total of 3051 midlife women were included in the present study. In early perimenopausal women, the odds ratios (ORs) of anxiety in the crude model indicated that beta-carotene intake was inversely associated with anxiety. After additional adjustment for age, race/ethnicity, education, income, financial strain, physical activity, BMI, vasomotor symptoms (VMS), chronic stress, use of antidepressant and total caloric intake in model 1, the results were similar to those of the crude model. This association remained statistically significant and changed little when additional controlling for estradiol, testosterone and sex hormone binding globulin (SHBG) in the fully adjusted model 2. The fully adjusted ORs and 95% confidence intervals (CIs) were 0.606 (0.408-0.901). However, in premenopausal women, no statistically significant difference was observed between beta-carotene intake and anxiety. Limitations: This was a cross-sectional study, limiting causal inferences. Conclusion: Dietary beta-carotene intake may be inversely associated with anxiety in early perimenopausal women, but not in premenopausal women.