Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast cancer

被引：20

作者：

Kim, Jun Ho ^{[2
]}

Cho, Young Hye ^{[1
]}

Park, Yong Lai ^{[2
]}

Sohn, Jin Hee ^{[1
]}

Kim, Hee Sung ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Pathol, Kangbuk Samsung Hosp, Sch Med, Seoul 110746, South Korea

[2] Sungkyunkwan Univ, Dept Surg, Kangbuk Samsung Hosp, Sch Med, Seoul 110746, South Korea

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 04期

关键词：

breast cancer; IGF-IR; IGFBP-3; immunocytochemistry; SURVIVAL; OVEREXPRESSION; SYSTEM; CELLS; RISK; VIVO;

D O I：

10.3892/or_00000724

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed insulin-like growth factor receptor I (IGF-IR) and insulin growth factor binding protein-3 (IGFBP-3) expression with respect to overall survival and relapse-free survival (RFS) in 460 patients with primary invasive breast cancer using immunohistochemistry. IGF-IR expression had a significant positive correlation with positive estrogen receptor (ER), positive progesterone receptor (PR) and Bcl-2 expression. Univariate analysis showed significantly C better overall survival (p=0.0001) and RFS (p=0.004), ill the IGF-IR-positive Group. Multivariate analysis showed a significant reduction in relative risk for overall Survival (p=0.019, HR=0.221, 95% CI=0.062-0.780) and RFS (p=0.026, HR=0.462 95% CI=0.234-0.913) in the IGF-IR-positive group. IGF-IR expression in primary breast cancer is an independent favorable prognostic factor. IGFBP-3 expression in breast cancer is associated with Poor outcome.

引用

页码：989 / 995

页数：7

共 27 条

[1]

BONNETERRE J, 1990, CANCER RES, V50, P6931

[2]

Chong YM, 2006, ANTICANCER RES, V26, P167

[3] Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor [J].

Chott, A ;

Sun, Z ;

Morganstern, D ;

Pan, J ;

Li, T ;

Susani, M ;

Mosberger, I ;

Upton, MP ;

Bubley, GJ ;

Balk, SP .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (04) :1271-1279

[4]

CULLEN KJ, 1990, CANCER RES, V50, P48

[5]

FOEKENS JA, 1989, CANCER RES, V49, P7002

[6]

FOEKENS JA, 1989, CANCER-AM CANCER SOC, V63, P2139, DOI 10.1002/1097-0142(19890601)63:11<2139::AID-CNCR2820631112>3.0.CO

[7]

2-D

[8]

Greene F., 2002, AJCC cancer staging handbook: From the AJCC cancer staging manual, V6th

[9] Expression of insulin-like growth factor-1 receptor in human colorectal cancer [J].

Hakam, A ;

Yeatman, TJ ;

Lu, L ;

Mora, L ;

Marcet, G ;

Nicosia, SV ;

Karl, RC ;

Coppola, D .

HUMAN PATHOLOGY, 1999, 30 (10) :1128-1133

[10] The insulin-like growth factor system in advanced breast cancer [J].

Helle, SI .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 18 (01) :67-79

← 1 2 3 →