Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

被引：58

作者：

Dominguez-Alvarez, Enrique ^{[1
,2
]}

Gajdacs, Mario ^{[3
]}

Spengler, Gabriella ^{[3
]}

Antonio Palop, Juan ^{[1
]}

Marc, Malgorzata Anna ^{[2
]}

Kiec-Kononowicz, Katarzyna ^{[2
]}

Amaral, Leonard ^{[3
]}

Molnar, Joseph ^{[3
]}

Jacob, Claus ^{[4
]}

Handzlik, Jadwiga ^{[2
]}

Sanmartin, Carmen ^{[1
]}

机构：

[1] Univ Navarra, Sch Pharm, Dept Organ & Pharmaceut Chem, Irunlarrea 1, Pamplona 31010, Spain

[2] Jagiellonian Univ, Coll Med, Dept Technol & Biotechnol Drugs, Medyczna 9, PL-30688 Krakow, Poland

[3] Univ Szeged, Fac Med, Dept Med Microbiol & Immunobiol, Dom Ter 10, H-6720 Szeged, Hungary

[4] Saarland State Univ, Div Bioorgan Chem, Geb B2-1, D-66123 Saarbrucken, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 12期

关键词：

Selenium; Multidrug resistance (MDR); Selenoesters; Cancer; Apoptosis; MDR efflux pumps; ABCB1 efflux pump (P-glycoprotein); P-GLYCOPROTEIN; SELENIUM SUPPLEMENTATION; HYDANTOIN DERIVATIVES; MCF-7; CELLS; IN-VITRO; APOPTOSIS; CYCLOPHOSPHAMIDE; METHYLSELENOL; NANOPARTICLES; CYTOTOXICITY;

D O I：

10.1016/j.bmcl.2016.04.064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. Results showed that the selenoanhydride (1) and the selenoesters with ketone terminal fragments (9-11) exerted (1.7-3.6)-fold stronger efflux pump inhibitory action than the reference verapamil. In addition, those four derivatives triggered apoptotic events in more than 80% of the examined MDR mouse cells. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2821 / 2824

页数：4

共 37 条

[1] Modulation of Imatinib Cytotoxicity by Selenite in HCT116 Colorectal Cancer Cells [J].

Abdel-Aziz, Amal Kamal ;

Azab, Samar Saad Eldeen ;

Youssef, Samar Samir ;

El-Sayed, Abeer Mostafa ;

El-Demerdash, Ebtehal ;

Shouman, Samia .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2015, 116 (01) :37-46

[2] NUTRITION INTERVENTION TRIALS IN LINXIAN, CHINA - SUPPLEMENTATION WITH SPECIFIC VITAMIN MINERAL COMBINATIONS, CANCER INCIDENCE, AND DISEASE-SPECIFIC MORTALITY IN THE GENERAL-POPULATION [J].

BLOT, WJ ;

LI, JY ;

TAYLOR, PR ;

GUO, WD ;

DAWSEY, S ;

WANG, GQ ;

YANG, CS ;

ZHENG, SF ;

GAIL, M ;

LI, GY ;

YU, Y ;

LIU, BQ ;

TANGREA, J ;

SUN, YH ;

LIU, FS ;

FRAUMENI, JF ;

ZHANG, YH ;

LI, B .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (18) :1483-1492

[3] Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design [J].

Castellucci Estevam, Ethiene ;

Witek, Karolina ;

Faulstich, Lisa ;

Nasim, Muhammad Jawad ;

Latacz, Gniewomir ;

Dominguez-Alvarez, Enrique ;

Kiec-Kononowicz, Katarzyna ;

Demasi, Marilene ;

Handzlik, Jadwiga ;

Jacob, Claus .

MOLECULES, 2015, 20 (08) :13894-13912

[4] Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model [J].

Chakraborty, Pramita ;

Roy, Somnath Singha ;

Bhattacharya, Sudin .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 15 (04) :501-510

[5] Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin a randomized controlled trial - A randomized controlled trial [J].

Clark, LC ;

Combs, GF ;

Turnbull, BW ;

Slate, EH ;

Chalker, DK ;

Chow, J ;

Davis, LS ;

Glover, RA ;

Graham, GF ;

Gross, EG ;

Krongrad, A ;

Lesher, JL ;

Park, HK ;

Sanders, BB ;

Smith, CL ;

Taylor, JR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (24) :1957-1963

[6]

CORNWELL MM, 1987, J BIOL CHEM, V262, P2166

[7] Synthesis and antiproliferative activity of novel selenoester derivatives [J].

Dominguez-Alvarez, Enrique ;

Plano, Daniel ;

Font, Maria ;

Calvo, Alfonso ;

Prior, Celia ;

Jacob, Claus ;

Antonio Palop, Juan ;

Sanmartin, Carmen .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 73 :153-166

[8] Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial [J].

Duffield-Lillico, AJ ;

Dalkin, BL ;

Reid, ME ;

Turnbull, BW ;

Slate, EH ;

Jacobs, ET ;

Marshall, JR ;

Clark, LC .

BJU INTERNATIONAL, 2003, 91 (07) :608-612

[9]

Estevam E. C., 2016, J HAZARD MAT

[10] Selenium in Human Health and Disease [J].

Fairweather-Tait, Susan J. ;

Bao, Yongping ;

Broadley, Martin R. ;

Collings, Rachel ;

Ford, Dianne ;

Hesketh, John E. ;

Hurst, Rachel .

ANTIOXIDANTS & REDOX SIGNALING, 2011, 14 (07) :1337-1383

← 1 2 3 4 →