Eosinophilic leukemic transformation in polycythemia Rubra vera (PRV)

被引：3

作者：

Chim, CS ^{[1
]}

Ma, SK

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Queen Mary Hosp, Univ Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2005年 / 46卷 / 03期

关键词：

eosinophilic leukemia; hydroxyurea; polycythemia vera;

D O I：

10.1080/10428190400007649

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only. Cytogenetic study showed complex abnormalities including -5, -7, +8, suggestive of a secondary leukemia. The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies.

引用

页码：447 / 450

页数：4

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