Delayed Cardioprotective Effects of Hyperoxia Preconditioning Prolonged by Intermittent Exposure

被引:11
作者
Baharvand, Babak [5 ]
Dehaj, Mansour Esmaili [1 ,2 ]
Foadaddini, Mohsen [4 ]
Rasoulian, Bahram [7 ,8 ]
Poorkhalili, Khalil [6 ]
Aghai, Hannaneh Wahhab [4 ]
Khoshbaten, Ali [3 ,4 ]
机构
[1] Yazd Univ Med Sci, Fac Med, Dept Physiol, Yazd, Iran
[2] Baqiyatallah Univ Med Sci, Res Ctr Trauma, Tehran, Iran
[3] Baqiyatallah Univ Med Sci, Res Ctr Chem Injuries, Tehran, Iran
[4] Baqiyatallah Univ Med Sci, Dept Physiol & Biophys, Tehran, Iran
[5] Lorestan Univ Med Sci, Shohadaye Ashayer Hosp, Div Heart, Khorramabad, Iran
[6] Boohsher Univ Med Sci, Dept Physiol, Sch Med Sci, Tehran, Iran
[7] Lorestan Univ Med Sci, Fac Med, Dept Physiol, Khorramabad, Iran
[8] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran
关键词
hyperoxia; preconditioning; intermittent; infarct; arrhythmia; ISCHEMIA-REPERFUSION INJURY; REDUCES INFARCT SIZE; SPINAL-CORD ISCHEMIA; HYPERBARIC-OXYGEN; MYOCARDIAL PROTECTION; UP-REGULATION; RAT MODEL; TOLERANCE; HEART; MECHANISM;
D O I
10.1016/j.jss.2008.12.034
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. In our previous study, it was indicated that pre-exposing rats to normobaric hyperoxia could induce a late preconditioning against infarction and arrhythmia. In this study, attempts were made to know whether the intermittent pre-exposure to the same environment could prolong the late phase of hyperoxia preconditioning. Methods. In the first series of experiments, rats were divided into five groups; group 1 was pre-exposed to normal air (NOR) and the other groups to hyperoxic air (O-2 > 95%, 120 min once a d) 12, 24, 48, and 72 h (H12, H24, 1148, and H72 groups) before 30 min ischemia. In the second series of experiments, rats were pre-exposed to intermittent hyperoxic air (1, 2, or 3 consecutive d) at different times before being subjected to ischemia (H48, H2-48, H2-72, H3-72, and H3-96 groups). The infarct size was measured by triphenyltetrazolium chloride staining, and lead II of electrocardiogram recorded to monitor ischemic-induce d arrhythmia. Results. Compared with NOR group, the infarct size and incidence of arrhythmia were reduced significantly in 1124 and 1148 groups. When the exposure periods were enhanced to 2 d, the infarct size did not decrease significantly, but the incidence of arrhythmia reduced. When the pre-exposure times were enhanced to 3 d, both the infarct size and incidence of arrhythmia decreased significantly in H3-72 group, but not in H3-96 group. Conclusion. These results show that the late phase of hyperoxia preconditioning may last for more than 48 h and prolong by intermittent per-exposure to the same environment. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:53 / 59
页数:7
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