Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin

被引:68
作者
Lymberopoulos, Maria H. [1 ]
Pearson, Angela [1 ]
机构
[1] Univ Quebec, Inst Armand Frappier, INRS Energie, Laval, PQ H7V 1B7, Canada
关键词
UL24; nucleolus; nucleolin; fibrillarin; herpes simplex virus 1;
D O I
10.1016/j.virol.2007.01.028
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
UL24 of herpes simplex virus 1 is important for efficient viral replication, but its function is unknown. We generated a recombinant virus, vHA-UL24, encoding UL24 with an N-terminal hemagglutinin tag. By indirect immunofluorescence at 9 h post-infection (hpi), we detected HAUL24 in nuclear foci and in cytoplasmic speckles. HA-UL24 partially co-localized with nucleolin, but not with ICP8 or coilin, markers for nucleoli, viral replication compartments, and Cajal bodies respectively. HA-UL24 staining was often juxtaposed to that of another nucleolar protein, fibrillarin. Analysis of HSV-1-induced nucleolar modifications revealed that by 18 hpi, nucleolin staining had dispersed, and fibrillarin staining went from clusters of small spots to a few separate but prominent spots. Fibrillarin redistribution appeared to be independent of UL24. In contrast, cells infected with a UL24-deficient virus retained foci of nucleolin staining. Our results demonstrate involvernent of UL24 in dispersal of nucleolin during infection. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:397 / 409
页数:13
相关论文
共 61 条
[1]  
Andersen JS, 2002, CURR BIOL, V12, P1, DOI 10.1016/S0960-9822(01)00650-9
[2]   THE HERPES-SIMPLEX VIRUS U(L)20 PROTEIN COMPENSATES FOR THE DIFFERENTIAL DISRUPTION OF EXOCYTOSIS OF VIRIONS AND VIRAL MEMBRANE-GLYCOPROTEINS ASSOCIATED WITH FRAGMENTATION OF THE GOLGI-APPARATUS [J].
AVITABILE, E ;
WARD, PL ;
DILAZZARO, C ;
TORRISI, MR ;
ROIZMAN, B ;
CAMPADELLIFIUME, G .
JOURNAL OF VIROLOGY, 1994, 68 (11) :7397-7405
[3]  
Besse S, 1996, J CELL SCI, V109, P119
[4]   ROLE OF GLYCOPROTEIN-B OF HERPES-SIMPLEX VIRUS TYPE-1 IN VIRAL ENTRY AND CELL-FUSION [J].
CAL, WH ;
GU, BH ;
PERSON, S .
JOURNAL OF VIROLOGY, 1988, 62 (08) :2596-2604
[5]   To be or not to be in the nucleolus [J].
Carmo-Fonseca, M ;
Mendes-Soares, L ;
Campos, I .
NATURE CELL BIOLOGY, 2000, 2 (06) :E107-E112
[6]   ATP-dependent localization of the herpes simplex virus capsid protein VP26 to sites of procapsid maturation [J].
Chi, JHI ;
Wilson, DW .
JOURNAL OF VIROLOGY, 2000, 74 (03) :1468-1476
[7]   PML bodies: a meeting place for genomic loci? [J].
Ching, RW ;
Dellaire, G ;
Eskiw, CH ;
Bazett-Jones, DP .
JOURNAL OF CELL SCIENCE, 2005, 118 (05) :847-854
[8]   SENSITIVITY OF ARABINOSYLADENINE-RESISTANT MUTANTS OF HERPES-SIMPLEX VIRUS TO OTHER ANTIVIRAL DRUGS AND MAPPING OF DRUG HYPERSENSITIVITY MUTATIONS TO THE DNA-POLYMERASE LOCUS [J].
COEN, DM ;
FLEMING, HE ;
LESLIE, LK ;
RETONDO, MJ .
JOURNAL OF VIROLOGY, 1985, 53 (02) :477-488
[9]   2 DISTINCT LOCI CONFER RESISTANCE TO ACYCLOGUANOSINE IN HERPES-SIMPLEX VIRUS TYPE-1 [J].
COEN, DM ;
SCHAFFER, PA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2265-2269
[10]   THYMIDINE KINASE-NEGATIVE HERPES-SIMPLEX VIRUS MUTANTS ESTABLISH LATENCY IN MOUSE TRIGEMINAL GANGLIA BUT DO NOT REACTIVATE [J].
COEN, DM ;
KOSZVNENCHAK, M ;
JACOBSON, JG ;
LEIB, DA ;
BOGARD, CL ;
SCHAFFER, PA ;
TYLER, KL ;
KNIPE, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4736-4740