An unusual case of chronic lymphocytic leukemia with trisomy 12 and t (14;18) and a favorable response to ibrutinib

被引：4

作者：

Haddad, Fady Gh ^{[1
]}

Chebly, Alain ^{[2
]}

El Sett, Antoine ^{[1
]}

Kourie, Hampig Raphael ^{[1
]}

Farra, Chantal ^{[2
,3
]}

机构：

[1] St Joseph Univ, Fac Med, Dept Hematol & Oncol, Beirut, Lebanon

[2] St Joseph Univ, Fac Med, Med Genet Unit, Beirut, Lebanon

[3] Hotel Dieu France Med Ctr, Dept Genet, Beirut, Lebanon

来源：

LEUKEMIA RESEARCH REPORTS | 2021年 / 15卷

关键词：

Chronic lymphocytic leukemia; CLL; trisomy; 12; t(14 18); ibrutinib; VENETOCLAX;

D O I：

10.1016/j.lrr.2021.100245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia. Chromosomal abnormalities are reported to play important roles in CLL pathogenesis and evolution, including deletions of 11q, 13q, 17p, and trisomy12, that are frequently observed and have a known prognostic value. Furthermore, the mutational status of the IGHV gene was reported as an independent prognostic marker in CLL impacting the choice of therapy. We herein, report an unusual presentation of a Lebanese CLL patient with two cytogenetic abnormalities: trisomy 12 and t(14;18)(q32;q21), along with an unmutated IGHV, displaying a favorable response to ibrutinib with a maintained complete remission.

引用

页数：4

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