The Current State of Stem Cell Therapy for Peripheral Artery Disease

被引：38
作者：
Gupta, Nitin K. [1 ,2 ]
Armstrong, Ehrin J. [3 ,4 ]
Parikh, Sahil A. [1 ,2 ]
机构：
[1] Univ Hosp Case Med Ctr, Harrington Heart & Vasc Inst, Div Cardiovasc Med, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA
[3] Univ Colorado, Sch Med, Div Cardiol, Denver, CO USA
[4] VA Eastern Colorado Healthcare Syst, Denver, CO USA
来源：
CURRENT CARDIOLOGY REPORTS | 2014年 / 16卷 / 02期
关键词：
Stem cells; Peripheral artery disease; Critical limb ischemia; CRITICAL LIMB ISCHEMIA; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW-CELLS; MONONUCLEAR-CELLS; POSTNATAL NEOVASCULARIZATION; DOUBLE-BLIND; AUTOLOGOUS TRANSPLANTATION; RESTORE-CLI; MOUSE MODEL; PLACEBO;
D O I：
10.1007/s11886-013-0447-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.
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页数：9
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