Synthesis and biological evaluation of benzoxazole fused combretastatin derivatives as anticancer agents

被引：36

作者：

Reddy, N. Bramhananda ^{[1
]}

Burra, Venkata Ramudu ^{[1
]}

Ravindranath, L. K. ^{[1
]}

Sreenivasulu, Reddymasu ^{[2
]}

Kumar, V. Naresh ^{[3
]}

机构：

[1] Sri Krishnadevaraya Univ, Dept Chem, Anantapur 515005, Andhra Pradesh, India

[2] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India

[3] Sri Chaitanya PG Coll, Dept Chem, Godavarikhani 505209, India

来源：

MONATSHEFTE FUR CHEMIE | 2016年 / 147卷 / 03期

关键词：

Combretastatin A-4; Benzoxazole; Sulforhodamine B assay; Anticancer activity; ANTINEOPLASTIC AGENTS; TUBULIN INHIBITORS; PHOSPHATE; COLCHICINE; MECHANISM; BINDING; POTENT; SERIES; A-4;

D O I：

10.1007/s00706-016-1685-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of ten novel benzoxazole analogues of combretastatin A-4 were designed, synthesized, and evaluated for their anticancer activity against three human cancer cell lines. Four of the synthesized compounds exhibited superior potency against different tumour cell lines. One of them showed more potent than control drug, particularly A549 and MCF-7 cell lines. [GRAPHICS] .

引用

页码：593 / 598

页数：6

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