One-pot synthesis of N-Cbz-α-aminophosphonic acids

被引：4

作者：

Vinyukov, Alexei V. ^{[1
]}

Dmitriev, Maxim E. ^{[1
]}

Ragulin, Valery V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiol Act Cpds, Severny Pr 1, Chernogolovka 142432, Moscow Region, Russia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2017年 / 192卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

Amidoalkylation; phosphoisosteres of amino acids; triacetylphosphite; acylimine cation; arbuzov-type reaction; aminoalkylphosphonic acids; TRIVALENT PHOSPHORUS; HYDROPHOSPHORYL COMPOUNDS; IN-SITU; AMIDOALKYLATION; DERIVATIVES; PEPTIDES; ANALOGS;

D O I：

10.1080/10426507.2016.1248289

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The paper describes the synthesi of N-protected-alpha-aminoalkylphosphonic acids, phosphoisosteres of amino acids, from phosphorous acid. A simple, milder and effective one-pot procedure for the amidoalkylation of phosphorous acid in a mixture of acetic anhydride and acetyl chloride at room temperature allows to combine the formation of amino phosphorylic function with the protection on the nitrogen atom.

引用

页码：437 / 441

页数：5

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