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Social interactions in the Burkholderia cepacia complex: biofilms and quorum sensing
被引:42
作者:
Coenye, Tom
[1
]
机构:
[1] Univ Ghent, Lab Pharmaceut Microbiol, B-9000 Ghent, Belgium
关键词:
antimicrobial resistance;
biofilm;
Burkholderia cepacia;
complex;
quorum sensing;
PSEUDOMONAS-AERUGINOSA BIOFILMS;
TOLERANT PERSISTER CELLS;
TRANSITION-METAL GALLIUM;
CYSTIC-FIBROSIS PATIENTS;
IN-VITRO;
ANTIBIOTIC-RESISTANCE;
EXOPOLYSACCHARIDE PRODUCTION;
HYDROGEN-PEROXIDE;
SIGMA-FACTOR;
STAPHYLOCOCCUS-AUREUS;
D O I:
10.2217/FMB.10.68
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B. cepacia complex bacteria can form biofilms, not only on abiotic surfaces (e.g., glass and plastics), but also on biotic surfaces such as epithelial cells, leading to the suggestion that biofilm formation plays a key role in persistent infection of cystic fibrosis lungs. This article presents an overview of the molecular mechanisms involved in B. cepacla complex biofilm formation, the increased resistance of sessile B. cepacia complex cells and the role of quorum sensing in B. cepacia complex biofilm formation.
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页码:1087 / 1099
页数:13
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