NEW POSSIBILITIES OF CORRECTION OF CLINICAL STATUS AND ENDOTHELIAL DYSFUNCTION IN CORONARY HEART DISEASE PATIENTS

被引：0

作者：

Kuzminova, N. V. ^{[1
,2
]}

Romanova, V. O. ^{[1
,2
]}

Syerkova, V. K. ^{[1
,2
]}

Bilovol, O. M. ^{[1
,2
]}

Knyazkova, I. I. ^{[1
,2
]}

Havrylyuk, A. O. ^{[1
,2
]}

机构：

[1] Vinnitsa Natl Med Univ MI Pyrohova, Vinnytsia, Vinnitsa, Ukraine

[2] Kharkiv Natl Med Univ, Kharkov, Ukraine

来源：

WORLD OF MEDICINE AND BIOLOGY | 2019年 / 69卷 / 03期

关键词：

coronary heart disease; endothelial dysfunction; meldonium; gamma-butyrobetaine;

D O I：

10.26724/2079-8334-2019-3-69-89-94

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

112 patients with coronary heart disease (CHD) were examined: 76 of them were diagnosed with stable CHD, 36 patients were hospitalized with acute coronary syndrome. To assess the effectiveness of treatment, patients were divided into two groups. The first group (n=69) received complex basic therapy of coronary heart disease. Patients of the second group (n=43) additionally to basic therapy received a fixed combination of meldonium (180 mg) with gamma-butyrobetaine (60 mg) orally 2 capsules twice daily during 4 weeks. Complex therapy of CHD patients with the combination of meldonium and gamma-butyrobetaine (was evaluated 1 month after start) contributed to a significant (p<0,05) improvement of both patients clinical condition (quality of life, reduction of angina attacks frequency, increased of treatment satisfaction) and functional status of endothelium (its vasomotor and adhesive functions) compared to traditional therapy.

引用

页码：89 / +

页数：7

共 15 条

[1] Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease [J].

Camici, Giovanni G. ;

Savarese, Gianluigi ;

Akhmedov, Alexander ;

Luescher, Thomas F. .

EUROPEAN HEART JOURNAL, 2015, 36 (48) :3392-U109

[2] NONINVASIVE DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADULTS AT RISK OF ATHEROSCLEROSIS [J].

CELERMAJER, DS ;

SORENSEN, KE ;

GOOCH, VM ;

SPIEGELHALTER, DJ ;

MILLER, OI ;

SULLIVAN, ID ;

LLOYD, JK ;

DEANFIELD, JE .

LANCET, 1992, 340 (8828) :1111-1115

[3]

Katerenchuk IP, 2015, KARDIOLOGIYA OT NAUK, V15, P27

[4]

Korzh AN, 2015, SERTSE SUDYNY, V2, P50

[5]

Kovalenko VM, 2015, STRES KHVOROBY SYSTE

[6]

Kuzminova NV, 2016, ARTER HYPERTENS, V20, P60, DOI 10.5603/AH.2016.0010

[7] 2013 ESC guidelines on the management of stable coronary artery disease [J].

Montalescot, Gilles ;

Sechtem, Udo ;

Achenbach, Stephan ;

Andreotti, Felicita ;

Budaj, Andrzej ;

Bugiardini, Raffaele ;

Crea, Filippo ;

Cuisset, Thomas ;

Di Mario, Carlo ;

Rafael Ferreira, J. ;

Gersh, Bernard J. ;

Gitt, Anselm K. ;

Hulot, Jean-Sebastien ;

Marx, Nikolaus ;

Opie, Lionel H. ;

Pfisterer, Matthias ;

Prescott, Eva ;

Ruschitzka, Frank ;

Sabate, Manel ;

Senior, Roxy ;

Taggart, David Paul ;

van der Wall, Ernst E. ;

Vrints, Christiaan J. M. ;

Knuuti, Juhani ;

Valgimigli, Marco ;

Bueno, Hector ;

Claeys, Marc J. ;

Donner-Banzhoff, Norbert ;

Erol, Cetin ;

Frank, Herbert ;

Funck-Brentano, Christian ;

Gaemperli, Oliver ;

Gonzalez-Juanatey, Jose R. ;

Hamilos, Michalis ;

Hasdai, David ;

Husted, Steen ;

James, Stefan K. ;

Kervinen, Kari ;

Kolh, Philippe ;

Kristensen, Steen Dalby ;

Lancellotti, Patrizio ;

Maggioni, Aldo Pietro ;

Piepoli, Massimo F. ;

Pries, Axel R. ;

Romeo, Francesco ;

Ryden, Lars ;

Simoons, Maarten L. ;

Sirnes, Per Anton ;

Steg, Ph. Gabriel ;

Timmis, Adam .

EUROPEAN HEART JOURNAL, 2013, 34 (38) :2949-+

[8]

Prikhodko VYu, 2015, SEMEYNAYA MED, V62, P47

[9]

Serkova VK, 2017, P SPIE INT SOC OPTIC

[10]

Sjakste N., 2006, PHARMACOLOGYONLINE, V1, P1

← 1 2 →