Paradoxical activation of alternative pro-survival pathways determines resistance to MEK inhibitors in chronic lymphocytic leukaemia

被引：6

作者：

Chen, Yixiang ^{[1
,2
]}

Germano, Sandra ^{[1
,2
]}

Shelmani, Ghalia ^{[1
,2
]}

Kluczna, Diana ^{[1
,2
]}

Jayne, Sandrine ^{[2
,3
]}

Dyer, Martin J. S. ^{[2
,3
]}

Macip, Salvador ^{[1
,2
]}

机构：

[1] Univ Leicester, Dept Mol & Cell Biol, Mech Canc & Ageing Lab, Leicester, Leics, England

[2] Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester, Leics, England

[3] Univ Leicester, Dept Canc Studies, Leicester, Leics, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2018年 / 182卷 / 06期

关键词：

CLL; MEK inhibitors; MAPK; CRAF; AKT;

D O I：

10.1111/bjh.14880

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：921 / 924

页数：4

共 3 条

[1] Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia [J].

Chen, Yixiang ;

Germano, Sandra ;

Clements, Chris ;

Samuel, Jesvin ;

Shelmani, Ghalia ;

Jayne, Sandrine ;

Dyer, Martin J. S. ;

Macip, Salvador .

BRITISH JOURNAL OF HAEMATOLOGY, 2016, 175 (04) :641-651

[2] Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls [J].

Dyer, Martin J. S. ;

Vogler, Meike ;

Samuel, Jesvin ;

Jayne, Sandrine ;

Wagner, Simon ;

Pritchard, Catrin ;

Macip, Salvador .

BRITISH JOURNAL OF HAEMATOLOGY, 2013, 160 (06) :725-733

[3] Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy [J].

Muzio, Marta ;

Apollonio, Benedetta ;

Scielzo, Cristina ;

Frenquelli, Michela ;

Vandoni, Irene ;

Boussiotis, Vassiliki ;

Caligaris-Cappio, Federico ;

Ghia, Paolo .

BLOOD, 2008, 112 (01) :188-195

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