Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms

被引：10

作者：

Gugliotta, Luigi ^{[1
]}

Iurlo, Alessandra ^{[2
]}

Gugliotta, Gabriele ^{[1
]}

Tieghi, Alessia ^{[3
]}

Specchia, Giorgina ^{[4
]}

Gaidano, Gianluca ^{[5
]}

Scalzulli, Potito R. ^{[6
]}

Rumi, Elisa ^{[7
]}

Dragani, Alfredo ^{[8
]}

Martinelli, Vincenzo ^{[9
]}

Santoro, Cristina ^{[10
]}

Randi, Maria Luigia ^{[11
]}

Tagariello, Giuseppe ^{[12
]}

Candoni, Anna ^{[13
]}

Cattaneo, Daniele ^{[2
]}

Ricco, Alessandra ^{[4
]}

Palmieri, Raffaele ^{[14
]}

Liberati, Marina A. ^{[15
]}

Langella, Maria ^{[16
]}

Rago, Angela ^{[17
]}

Bergamaschi, Micaela ^{[18
]}

Monari, Paola ^{[19
]}

Miglio, Rossella ^{[19
]}

Santoro, Umberto ^{[20
]}

Cacciola, Rossella ^{[21
]}

Rupoli, Serena ^{[22
]}

Mastrullo, Lucia ^{[23
]}

Musto, Pellegrino ^{[24
]}

Mazzucconi, Maria Gabriella ^{[10
]}

Vignetti, Marco ^{[10
]}

Cortelezzi, Agostino ^{[2
]}

Vianelli, Nicola ^{[1
]}

Martino, Bruno ^{[25
]}

De Stefano, Valerio ^{[26
]}

Passamonti, Francesco ^{[27
]}

Vannucchi, Alessandro M. ^{[28
]}

机构：

[1] S Orsola Malpighi Univ Hosp, Hematol Inst LeA Seragnoli, Via Massarenti 9, I-40138 Bologna, Italy

[2] Maggiore Hosp, Univ Polyclin, IRCCS Ca Granda Fdn, Dept Hematol, Milan, Italy

[3] Azienda Osped Arcispedale S Maria Nuova IRCCS, Dept Hematol, Reggio Emilia, Italy

[4] Univ Hosp Giovanni XXIII, Dept Hematol, Bari, Italy

[5] Amedeo Avogadro Univ Eastern Piedmont, Dept Hematol, Novara, Italy

[6] IRCCS Casa Sollievo Sofferenza, Dept Hematol, San Giovanni Rotondo, Italy

[7] Univ Hosp, Dept Hematol, IRCCS S Matteo, Pavia, Italy

[8] S Spirito Hosp, Dept Hematol, Pescara, Italy

[9] Univ Naples Federico II, Dept Hematol, Naples, Italy

[10] Univ Roma La Sapienza, Cellular Biotechnol & Hematol Dept, Rome, Italy

[11] Univ Hosp, Dept Internal Med, DIMED, Padua, Italy

[12] S Giacomo Apostolo Hosp, Hematol & Transfus Dept, Castelfranco Veneto, Italy

[13] Univ Hosp S Maria della Misericordia, Dept Hematol, Udine, Italy

[14] S Giuseppe Moscati Hosp, Hematol Unit, Avellino, Italy

[15] S Maria Hosp, Oncohematol Dept, Terni, Italy

[16] Osped Civ, Hematol Unit, Nocera Inferiore, Italy

[17] S Maria Goretti Hosp ICOT, Hematol Unit, Latina, Italy

[18] Univ Hosp, Dept Hematol, Genoa, Italy

[19] Univ Bologna, Dept Stat Sci, Bologna, Italy

[20] Ist Ortoped Rizzoli IRCCS, Med Technol Lab, Bologna, Italy

[21] Univ Catania, Dept Clin & Mol Biomed, Hemostasis Unit, Catania, Italy

[22] Univ Hosp, Dept Hematol, Ancona, Italy

[23] San Gennaro San Giovanni Bosco Hosp, Dept Hematol, Naples, Italy

[24] CROB, Dept Hematol, IRCCS, Rionero In Vulture, Italy

[25] Bianchi Melacrino Morelli Hosp, Dept Hematol, Reggio Di Calabria, Italy

[26] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Dept Hematol, I-00168 Rome, Italy

[27] Az Osped Univ, Dept Hematol, Osped Circolo, Varese, Italy

[28] Univ Hosp, Dept Hematol, Florence, Italy

来源：

LEUKEMIA RESEARCH | 2016年 / 46卷

关键词：

Thrombocythemia; Thrombosis; Platelets; Leukocytes; Hematocrit; JAK2; DEFINED ESSENTIAL THROMBOCYTHEMIA; RISK-FACTORS; POLYCYTHEMIA-VERA; VASCULAR COMPLICATIONS; MUTATION STATUS; HYDROXYUREA; SURVIVAL; LEUKOCYTOSIS; ANAGRELIDE; CRITERIA;

D O I：

10.1016/j.leukres.2016.04.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), the anti-thrombotic and/or cytoreductive treatment in the follow-up may affect the evaluation of the pro-thrombotic weight of the clinical and biological characteristics at diagnosis. In order to avoid this potential confounding effect, we investigated the relationship between prior thrombosis (PrTh: thrombosis occurred before diagnosis and before treatment) and the characteristics at diagnosis in 977 thrombocythemic patients with MPN, reclassified according to the WHO 2008 criteria. PrTh occurred in 194 (19.9%) patients, with similar rates in the different MPNs. In multivariate analysis, PrTh rate was significantly related to minor thrombocytosis (platelets <= 700 x 10(9)/L), leukocytosis (leukocytes > 10 x 10(9)/L), higher hematocrit (HCT > 45%), JAK2 V617F mutation, older age, and cardiovascular risk factors (CVRFs). The highest PrTh rate (33.9%) was associated with the coexistence of minor thrombocytosis and leukocytosis. Of note, the inverse relationship between PrTh rate and platelet count is consistent with the hemostatic paradox of thrombocytosis. In conclusion, this analysis in MPN patients disclosed the unbiased characteristics at diagnosis with a pro-thrombotic effect. Moreover, it suggests that the optimal control of blood cells counts, and CVRFs might be of utmost importance in the prevention of thrombosis during the follow-up. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：18 / 25

页数：8

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