Candidate gene association study of insulin signaling genes and Alzheimer's disease:: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci

被引：48

作者：

Hamilton, Gillian

Proitsi, Petra

Jehu, Luke

Morgan, Angharad

Williams, Julie

O'Donovan, Michael C.

Owen, Michael J.

Powell, John F.

Lovestone, Simon

机构：

[1] Kings Coll London, MRC, Ctr Neurodegenerat Res, Dept Neurosci,Inst Psychiat, London WC2R 2LS, England

[2] Cardiff Univ, Sch Med, Dept Med Psychol, Cardiff, Wales

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2007年 / 144B卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

genetics; late-onset Alzheimer's disease; association; type II diabetes;

D O I：

10.1002/ajmg.b.30503

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes-PPAR gamma, SOS2, and PCK1-with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. (c) 2007 Wiley-Liss, Inc.

引用

页码：508 / 516

页数：9

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